Figure 7

Comparison of glomerular proteome with urine proteome. Excretion of glomerular proteins into urine was roughly estimated by comparison with a high-confidence, non-redundant dataset of normal human urine proteome [15]. In Panel A, the two proteome datasets were directly compared to estimate overlapped proteins. Among the 445 overlapped proteins representing 24.5% of the glomerular proteome, 95 proteins annotated as “extracellular space” (presumably representing plasma proteins) by GO Cellular Component vocabulary were found. In Panel B, the two proteome datasets from which “extracellular space” proteins were depleted were compared to estimate glomerular proteins excreted into urine by removing plasma proteins which were identified in both proteomes.