Figure 5

LPS, but not CRP, mediates effects via NF-κB and MAPKinase-signaling pathways. In the LPS treated group increased phosphorylation of JNK, p38 and ERK and degradation of IKBα are detected by Western blotting. There is no significant signal transduction in either the mCRP or pCRP treated group through these pathways when compared to control. This result demonstrates that p- and mCRP are not sharing these signal transduction pathways with LPS and that the results of this study are not confounded by LPS contamination.