Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses

Table 3 IPA-based functional category "cancer" correlates with the identified ERβ-interacting proteins.

IPA function	Total number of proteins identified	Protein
			H1793	H1793	A549	A549
			EtOH	E ₂	EtOH	E ₂
cancer	12	ACTB,	+	+	+	+
		EEF1A1,				+
		ESR2,	+	+	+	+
		HSPA8,	+	+
		MYL12A,			+
		NCL		+
		PLEC,		+
		RAN,	+
		TPM1,			+	+
		TPM3,		+
		TUBB2A,	+	+	+	+
		VIM	+	+
malignant tumor	7	EEF1A1,				+
		ESR2,	+	+	+	+
		HSPA8,	+	+
		MYL12A,			+
		NCL,		+
		TUBB2A,	+	+	+	+
		VIM	+	+
non-small-cell lung cancer	5	EEF1A1,				+
		ESR2,	+	+	+	+
		MYL12A,			+
		TUBB2A,	+	+	+	+
		VIM	+	+
metastasis	4	ACTB,	+	+	+	+
		ESR2,	+	+	+	+
		TUBB2A,	+	+	+	+
		VIM	+	+

The ERβ-interacting proteins are from Supplemental Tables 2 and 3. The total number of proteins in the IPA classification are indicated followed by the protein name. The + means that protein was identified in the indicated cell line (H1792 or A549) after EtOH or E₂ treatment.

ISSN: 1477-5956