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Table 3 Peptides set as biomarkers differentially detected between fertilized group and non-fertilized group

From: Follicular fluid biomarkers for human in vitro fertilization outcome: Proof of principle

m/z

RT

Charge

Highest mean condition

max fold change

Protein

Accession number

Peptide sequence

Exp.1

Exp.2

401.22 ± 0.00

28.2 ± 0.11

2*

non-fertilized

8.94b

3.07c

ALBU_Human

P02768

AASQAALGL

402.23 ± 0.00

25.3 ± 0.66

1

non-fertilized

2.16b

2.44c

   

409.18 ± 0.00

24.8 ± 0.22

1

non-fertilized

2.7a

1.99b

   

410.17 ± 0.00

36.4 ± 0.26

1

fertilized

3.09a

11.07b

   

412.34 ± 0.00

44.3 ± 0.02

1*

non-fertilized

3.36b

2.78b

   

414.34 ± 0.01

43.3 ± 2.37

1*

non-fertilized

1.93c

2.00c

   

416.37 ± 0.00

46.0 ± 0.15

1*

non-fertilized

2.11c

14.22a

   

424.29 ± 0.01

46.5 ± 0.15

1*

fertilized

4.18b

2.24a

   

426.32 ± 0.02

48.0 ± 0.77

1

fertilized

1.49c

2.33b

   

438.36 ± 0.02

52.4 ± 1.14

1

non-fertilized

2.67c

2.76a

   

439.28 ± 0.00

25.0 ± 0.38

1*

non-fertilized

2.88b

215.28b

   

442.94 ± 0.00

27.2 ± 0.60

3

non-fertilized

21.09b

2.57a

   

459.72 ± 0.00

22.1 ± 0.30

2*

non-fertilized

27.37b

12.84b

   

475.01 ± 0.00

23.4 ± 0.48

4*

non-fertilized

5.63b

1.77b

   

477.28 ± 0.00

47.6 ± 0.48

1*

non-fertilized

25.53a

25.84c

   

478.62 ± 0.00

41.8 ± 0.00

3*

non-fertilized

3.02b

1.18c

   

480.80 ± 0.00

40.5 ± 0.82

2*

fertilized

1.22c

1.30c

   

490.24 ± 0.02

46.5 ± 0.25

1

fertilized

1.70b

8.68c

   

494.29 ± 0.02

46.4 ± 0.97

1*

non-fertilized

549.84a

2.59b

IGBP-5_Human

P24593

FVGGAENTAHPRII

496.97 ± 0.00

43.1 ± 0.39

3

fertilized

1.36b

1.40b

   

500.24 ± 0.00

26.7 ± 0.26

3

non-fertilized

341.3c

2.55c

   

526.41 ± 0.02

52.1 ± 1.08

1

non-fertilized

3.59b

3.10a

   

528.28 ± 0.00

34.1 ± 0.11

2*

fertilized

3.61b

1.94c

CO3_Huamn

P01024

IHWESASLL

530.29 ± 0.00

45.8 ± 1.13

1*

fertilized

1.87c

6.26c

   

539.66 ± 0.00

44.7 ± 0.41

6

non-fertilized

2.08b

1.73b

   

545.33 ± 0.00

44.8 ± 0.26

6

non-fertilized

Infinita

2.08b

   

546.99 ± 0.00

44.7 ± 0.42

6

non-fertilized

1.93b

1.60b

   

552.30 ± 0.00

28.7 ± 0.11

5

non-fertilized

68.46c

2.24b

   

552.67 ± 0.00

44.7 ± 0.40

6

non-fertilized

3.05c

1.60c

   

554.33 ± 0.00

44.7 ± 0.41

6

non-fertilized

2.00c

1.70b

   

558.40 ± 0.00

51.1 ± 0.31

2

non-fertilized

1795.51a

Infinita

   

570.43 ± 0.02

51.9 ± 1.06

1

non-fertilized

4.31b

3.77c

   

574.68 ± 0.00

44.8 ± 0.40

6

non-fertilized

4.33b

2.39c

   

576.35 ± 0.00

44.8 ± 0.41

6

non-fertilized

2.24b

1.94b

   

577.28 ± 0.00

33.5 ± 0.77

1*

non-fertilized

1.42b

2.26b

   

579.18 ± 0.00

44.8 ± 0.39

6

non-fertilized

2.19b

1.95c

   

588.43 ± 0.01

45.5 ± 1.66

1

non-fertilized

43.29b

4.46c

   

594.30 ± 0.00

24.0 ± 0.14

2*

fertilized

3.09b

2.90a

ITIH1_human

P19827

LPDRVTGVDTD

602.42 ± 0.00

51.4 ± 1.02

2

non-fertilized

164.28c

Infinita

   

609.72 ± 0.00

30.0 ± 0.00

5

non-fertilized

10.0b

1.91a

   

643.33 ± 0.00

29.0 ± 1.59

2*

non-fertilized

Infinitc

2.59a

A2AP_human

P08697

MEPLGRQLTSGP

658.49 ± 0.02

51.7 ± 0.99

1

non-fertilized

7.59b

11.57b

   

702.51 ± 0.02

51.6 ± 1.01

1

non-fertilized

6.36b

12.66c

   

703.75 ± 0.00

31.1 ± 1.97

5

non-fertilized

Infinita

1.79b

   

727.59 ± 0.00

28.0 ± 0.07

4*

non-fertilized

1266.81a

2.03b

   

740.96 ± 0.00

30.6 ± 0.05

5

non-fertilized

4.35b

1.91a

PLST_HUMAN

P13797

DGETLEELMKLSPEELLLRWANFHLENSGWQ

755.34 ± 0

12.2 ± 0.36

2

non-fertilized

2.04b

2.16a

   

761.97 ± 0.00

31.0 ± 0.01

5

non-fertilized

6.85b

2.10a

   

805.39 ± 0.00

35.8 ± 0.01

1*

non-fertilized

Infinitc

7.38b

   

859.44 ± 0.00

29.4 ± 0.04

4

non-fertilized

Infinita

2.94a

   

869.68 ± 0.00

32.7 ± 0.15

4

non-fertilized

Infinitb

3.92c

   

924.74 ± 0.00

38.0 ± 0.41

3*

non-fertilized

Infinitc

9.77b

   

953.51 ± 0.00

29.1 ± 0.23

3

non-fertilized

12.72b

3.24c

DIAP1_HUMAN

O60610

AEPHFLSILQHLLLVRNDYEARPQ

  1. a p < 0.01; b p < 0.05; c p < 0.1
  2. *:significant difference in validation experiment