Protein name | Accession # | RP | MW | Whole cohort | Male cohort | Female cohort | MS method | Mascot | Comment | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fraction ID | (kDa) | AD fold change | p-value | AD fold change | p-value | AD fold change | p-value | Score/ #peptides | ||||
Zinc α 2-glycoprotein (ZAG) | P25311 | 1a | 40 | 1.9 up | < 0.05 | NS | NS | NS | NS | 2 | NS | Most basic glycoform |
Zinc α 2-glycoprotein (ZAG) | P25311 | 1b | 40 | 1.5 up | < 0.05 | NS | NS | NS | NS | 2 | 111/4 | Most basic glycoform |
Zinc α 2-glycoprotein (ZAG) | P25311 | 1c | 40 | 1.3 up | 0.06 | NS | NS | NS | NS | 2 | 88/6 | NS but trending |
Histidine-rich glycoprotein (HRG) | P04196 | 1d | ~ 35 | 1.7 up | < 0.02 | NS | NS | 2.9 up | < 0.002 | 2 | 161/4 | Putative cleavage product |
Unidentified Series | n/a | 1e | ~ 40 | 1.5 down | < 0.05 | NS | NS | NS | NS | – | n/a | Low abundant species |
Haptoglobin (Hpt) heavy chain | P00738 | 2a | 40 | 2.0 up | < 0.01 | NS | NS | 2.2 up | < 0.02 | 2 | 238/13 | Summation of variants |
Haptoglobin (Hpt) mid chain | P00738 | 2b | 16 | NS | NS | NS | NS | NS | NS | 2 | a | NS changing subunit of Hpt |
Haptoglobin (Hpt) light chain | P00738 | 2c | 9 | 2.4 up | < 0.02 | NS | NS | NS | NS | 2 | a | Summation of variants |
Vitamin D binding protein (VDBP) | P02774 | 3b | ~ 50 | NS | NS | See Fig. 5 | Cleavage products | |||||
Vitamin D binding protein (VDBP) | P02774 | 3c | ~ 40 | NS | NS | See Fig. 5 | Multiple cleavage products | |||||
Vitamin D binding protein (VDBP) | P02774 | 3d | ~ 10 | NS | NS | See Fig. 5 | Multiple cleavage products | |||||
Inter α trypsin inhibitor heavy chain H4 (ITIH4) | Q14624 | 3e | ~ 12 | 1.3 up | < 0.05 | NS | NS | NS | NS | 3 | 428/5 | C-term clevage product |
Complement factor 1(CFI) | P05156 | 3f | ~ 53 | NS | NS | 2.5 up | < 0.01 | 2.6 down | < 0.02 | 2 | 64/2 | Putative cleavage product |
Complement factor 1(CFI) | P05156 | 3 g | ~ 53 | NS | NS | 2.0 up | < 0.001 | 2.4 down | < 0.03 | 2 | 78/2 | Putative cleavage product |
Complement factor 1(CFI) | P05156 | 3 h | ~ 53 | NS | NS | 3.6 up | 0.056 | 3.1 down | < 0.03 | 2 | 127/4 | Putative cleavage product |
Complement factor 1(CFI) | P05156 | 3i | ~ 53 | NS | NS | 4.0 up | < 0.1 | 3.1 down | 0.058 | 2 | 69/1 | NS but trending |
Inter α trypsin inhibitor heavy chain H4 (ITIH4) | Q14624 | 4a | ~ 40 | 1.3 up | < 0.05 | 1.5 up | < 0.02 | NS | NS | 3 | 890/14 | N-term cleavage product |
C-reactive binding protein (CRP) | P02741 | 4b | 25 | 3.2 up | 0.19 | NS | NS | NS | NS | 1 | 96/2 | NS change |
C-reactive binding protein (CRP) | P02741 | 4c | 25 | 2.9 up | 0.09 | NS | NS | NS | NS | 1 | NS | NS change |
C-reactive binding protein (CRP) | P02741 | 4d | 25 | 2.4 up | 0.18 | NS | NS | NS | NS | 1 | NS | NS change |
C-reactive binding protein (CRP) | P02741 | 4e | 25 | 2.2 up | 0.06 | NS | NS | NS | NS | 1 | NS | NS but trending |
α 1-antitrypsin (α1AT) | P01009 | 5a | ~ 47 | 3.3 | < 0.02 | NS | NS | NS | NS | 2 | 86/3 | |
Apolipoprotein E (ApoE) | P02649 | 5b | 34 | 1.5 up | < 0.02 | NS | NS | NS | NS | 2 | 149/7 | Epsilon 4 proxy |