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Table 1 Summary of mass spectrometric identification of biomarker candidates in the LDL, HDL, and protein fractions

From: Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D

Detection group

Fraction

Gene symbol

HC-onlya

LDL

ATP9A, CRK, SPECC1L, FN1, GIGYF2, HRG, IGHV3-15, SERPING1, Immunoglobulin epsilon heavy chainc, IGHG3, ITIH1, KRT6C, IGKV3D-20, IGLV1-47, IGLV8-61, MARK4, MYO10, URB1, PFN1, PSAP, SCN2A, SDPR, TAGLN2, TMEM198, TSHZ3

HDL

IGFALS, APOH, IGKV2D-26, PFN1, SHBG, ZNF587B

Protein

APOB, BAZ1A, CDH5, COMP, GZMM, HRNR, IFT46, IGLV8-61, MSH3, MCAM, NCAM1, NEFL, PRDX1, PFN1, PTPRG, SPP2

TAA-onlyb

LDL

APMAP, B2M, CFD, C4A, RYR2, SAA1

HDL

CFB, CFD, LUM, SLX4

Protein

ORM2, CFD, CRP, FBLN1, Immunoglobulin alpha-2 heavy chainc

  1. Bold font indicates commonly identified genes in the three SFUC fractions of either the HC-only or TAA-only group 
  2. aGenes commonly detected in the three SFUC fractions of the HC-only group, but not in those of the three TAA serum samples (Additional Files 3, 4 and 5)
  3. bGenes commonly detected in the three SFUC fractions of the TAA-only group but not in those of the HC serum sample (Additional Files 3–5)
  4. cBiomarker candidates are shown by protein names as they were not assigned to specific genes
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Proteome Science

ISSN: 1477-5956