Fig. 5

Inhibition of PKA-promoted cardiomyocyte replication and upregulated cell cycle–related genes. A Ki67 results of PKA inhibitor and activator; 5μM bucladesine inhibited cardiomyocyte replication (from 15.3% to 9.5%, p = 0.0047) and 1μM H-89 promoted cardiomyocyte replication (from 15.3% to 24.4%, p = 0.0017). B Western blotting results of PKA α/β/γ pT197, PKA α/β/γ, CDK4, CylinD1, and CylinE1