Table 1 Functional enrichment analysis of up-regulated proteins
From: Label-free quantitative proteomic analysis of serum exosomes in mice with thoracic aortic aneurysm
Enrichment Analysis | Annotation | Protein Species | FDR Values |
|---|---|---|---|
BP | Response to stress | 52 | 1.17E-17 |
BP | Regulation of immune system process | 27 | 2.47E-10 |
BP | Regulation of protein metabolic process | 36 | 1.33E-08 |
BP | Regulation of signal | 35 | 2.44E-07 |
BP | transduction | 13 | 3.76E-06 |
MF | Inflammatory response | 27 | 3.72E-08 |
MF | Signaling receptor binding | 27 | 6.32E-08 |
MF | molecular function regulator | 14 | 9.7E-08 |
MF | Enzyme inhibitor activity | 7 | 3.22E-06 |
MF | Enzyme regulator activity | 17 | 9.27E-06 |
KEGG | Complement and coagulation cascades | 10 | 1.71E-09 |
KEGG | HIF-1 signaling pathway | 4 | 0.0127 |
KEGG | Thyroid hormone synthesis | 3 | 0.0338 |
KEGG | ECM-receptor interaction | 3 | 0.0376 |
KEGG | Vitamin digestion and absorption | 2 | 0.0376 |
Reactome | Platelet activation, signaling and aggregation | 25 | 1.69E-24 |
Reactome | Plasma lipoprotein assembly, remodeling, and clearance | 4 | 0.0018 |
Reactome | Smooth muscle contraction | 3 | 0.0018 |
Reactome | Platelet adhesion to exposed collagen | 2 | 0.0065 |
Reactome | Crosslinking of collagen fibrils | 2 | 0.0153 |