Fig. 3
Comparative proteomic analysis between CHMp and CHMm exosomal proteins. A Gene Ontology (GO) analysis of statistically enriched in CHMp and CHMm exosomal proteins by the web tool DAVID v 6.8. (Yellow bars; BP, biological process. Green bars; CC, cellular component, blue bars; MF, molecular function). B STRING network analysis of differentially expressed proteins (DEPs) in CHMp exosomal proteins. Protein–Protein Interaction (PPI) network showing that CHMP exosomal proteins are enriched in proteasome, glycolysis/gluconeogenesis, splicing factor and extracellular matrix-collagen. C STRING network analysis of DEPs in CHMm exosomal proteins. CHMm exosomal proteins are enriched in Laminin. Proteins are shown as nodes. D-E Gene set enrichment analysis (GSEA) between DEPs in CHMp and CHMm exosomal proteins. D GSEA revealed carbohydrate catabolic process were significantly enriched in CHMp exosomal proteins. E Laminin pathways enriched in CHMm exosomal proteins