Table 3 Summary Of HotSpot Ligand Interactions With TNFR2
From: Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2
Phage | Size (aa) | Motif | Competed by TNF-alpha & TNF-Beta | Competed by Peptides | Competed by Anti-TNFR2 (mAb226) | Antagonism | Cytotoxic Response On SK-N-E cells | Cytotoxic Response Inhibited by |
|---|---|---|---|---|---|---|---|---|
KcF7 | 20 | No | + | + | + | + | + | mAb226 |
KcD11 | 20 | Yes | + | + | + | - | - | NA |
KcF6 | 20 | Yes | + | + | + | + | + | mAb226 |
KcF12 | 40 | No | + | + | - | + | + | KcD11 |