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Table 3 Summary Of HotSpot Ligand Interactions With TNFR2

From: Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2

Phage Size (aa) Motif Competed by TNF-alpha & TNF-Beta Competed by Peptides Competed by Anti-TNFR2 (mAb226) Antagonism Cytotoxic Response On SK-N-E cells Cytotoxic Response Inhibited by
KcF7 20 No + + + + + mAb226
KcD11 20 Yes + + + - - NA
KcF6 20 Yes + + + + + mAb226
KcF12 40 No + + - + + KcD11
  1. NA: Not applicable