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Table 1 Proteins identified in the human cerebral microdialysate. The upper part contains proteins also found in CSF, the lower part lists additional proteins found in the microdialysate which have not been described in CNS. The first column gives the consecutive number of the identified protein, the second column the number of spots in the two-dimensional gels belonging to the individual proteins. The third and fourth column displays the protein annotation as in the SwissProt database at http://www.expasy.ch. The amino acid composition or structural information about the proteins can be retrieved via the accession number in the fifth column. This database also contains the CSF protein map. The sixth and seventh column shows pI and molecular weight. Strictly speaking, the immunoglobulin fractions do not represent a single protein, but a protein family, therefore pI and molecular weight cannot be given.

From: The proteome of human brain microdialysate

Spot number Number of spots identified Gene name Protein description SwissProt accession number Theoretical pI Theoretical molecular weight (Da)
proteins identified in cerebral microdialysate and cerebrospinal fluid
1 8 SERPINA3 Alpha-1-antichymotrypsin P01011 5.33 47651
2 8 SERPINA1 Alpha-1-antitrypsin P01009 5.37 46737
3 5 A1BG Alpha-1B-glycoprotein P04217 5.65 51941
4 3 APOA1 Apolipoprotein A-I P02647 5.56 30778
5 1 AMBP AMBP protein P02760 5.95 38999
6 2 APOE Apolipoprotein E P02649 5.65 36154
7 2 C3 Complement C3 P01024 6.02 187164
8 1 FGG Fibrinogen gamma chain P02679 5.37 51512
9a 6 HP Haptoglobin-2 P00738 6.13 45205
9b 2 HP Haptoglobin alpha-2 chain P00738 5.57 15946
9c 2 HP Haptoglobin beta chain P00738 6.32 27265
10 7 -- Immunoglobulin heavy chain P99006 -- --
11 13 -- Immunoglobulin light chain P99007 -- --
12 1 RBP4 Plasma retinol-binding protein P02753 5.76 23044
13 4 PLG Plasminogen (EC 3.4.21.7) P00747 7.04 90569
14 5 ALB Albumin P02768 5.92 69367
15 5 TF Transferrin P02787 6.81 77050
16 2 TTR Transthyretin P02766 5.52 15887
17 2 GC Vitamin D-binding protein P02774 5.24 56761
proteins identified solely in cerebral microdialysate
18 1 B2M Beta-2 microglobulin P01887 7.80 13823
19 1 CKB Creatine kinase, B chain P12277 5.34 43644
20 1 DRP2 Dihydropyrimidinase related protein-2 Q16555 5.95 62294
21 4 GAPD Glyceraldehyde 3-phosphate dehydrogenase P16858 8.45 35679
22 1 HSP73 Heat shock protein 70 kD HSP73 P11142 5.37 70898
23 1 HBB Hemoglobin beta chain P02023 6.81 15867
24 1 MDHA Malate dehydrogenase P40925 6.89 36295
25 4 TUBA1 Tubulin alpha-1 P04687 4.94 50152
26 3 -- Tubulin beta Q13885 4.78 49907
27 1 TUBB5 Tubulin beta 5 Q8WUC1 4.78 49671