Figure 5

Proteins differentially expressed in (A) BT474 and (B) SKBR3 in comparison with 184A1 were overlaid onto a global molecular network developed from information contained in the Ingenuity Knowledge Base (IKB). Genes or gene products are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). Solid lines indicate a direct relationship and dashed lines indicate an indirect relationship between nodes. The intensity of the node color represents the degree of up- (red) or down- (green) regulation. White nodes represent the IKB molecules associated with focus genes. Network reflects (A) Cellular Function and Maintenance, Cell Death, and Protein Synthesis (p < 10^-48) and (B) Cell Morphology, Cellular Function and Maintenance, and Protein Degradation (p < 10^-57).