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Table 1 List of unique proteins that were differentially expressed and formed the dataset for IPA analysis are listed along with the associated fold-change and p-value.

From: Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer

BT-474 versus 184A1 SKBR3 versus 184A1
Gene Symbol Fold change a Gene Symbol Fold Change a Gene Symbol Fold change a Gene Symbol Fold change a
ACTB 1.9 ± 0.1 LYN 1.62 AKT2 -3.14 LMNA -2.6
ACTN4 -3.54 MCF2L 2 ALDH2 -1.72 LMNB1 1.98
ACTRT1 -3.75 NDE1 2.33 ANXA5 -6.5 MAP3K7 -4.95
ADSL -2.58 P4HB 2.9 ± 1.1 ANXA6 1.73 MPP2 2.37
ALCAM -21.5 PCYT1B -3.45 APOA1 -2.71 MRPS35 5.18
ALDH2 -2.63 PDE4D 2.45 ATP5B 3.03 NME5 -6.4
ANXA5 -20.5 ± 141 PDE4D -2.94 ATP5B -3.2 ± 0.6 NME7 -6.4
ANXA8L2 -4.24 PHB -2 BPNT1 -2.59 NQO2 -5.83
BCAR3 4.25 PIH1D1 -2.46 CAPN11 3.52 OPA1 -3.06
BID -3.19 PMM2 2.74 CMPK1 -2.56 P4HB 2.55
C10orf88 -3.28 POLR3E -2.12 CTNNA3 -3.46 PAF1 -1.97
CAPZB -2.05 PPFIBP1 2.23 EEF2K 6.03 POLI -2.11
CDKN2A 3.22 PPM1B 2.99 EIF2S1 -3.89 PPFIBP1 4.18
CSK -9.11 PRDX2 -5.03 EIF2S2 4.32 PPP1CC 8.87
DPYSL4 1.66 PRPSAP2 -2.87 EIF3I -3.89 PRDX6 3.21
EEFIG -2.73 PSMB1 1.76 EVC 10.12 PRKAR2A -19.47
EIF2B3 -3.95 PSMC2 -5.3 ± 2.5 FAM102B 2.08 PRPS1 -5.46
FSTL1 -7.6 PSMC4 -7.19 GDI2 -2.31 PRPSAP2 -2.31
GNA14 -3.1 PSME1 -2.2 ± 0.6 GNB1L -6.1 PSMA3 -3.25
GSTP1 -45.37 PTER -6.49 GOLGA8F 4.17 PSMB8 -3.7
HIBADH -2.86 RAB27B -1.83 GRK4 -2.8 ± 0.4 RAB37 -2.17
HORMAD1 -1.63 RAB37 -2.9 ± 0.4 GSTP1 -22.92 RABIL1 -3.01
HSPA1L -3.53 RAB3A 3.45 GTF3C4 3.69 RMND1 -3.13
HSPA5 2.21 RGN -1.62 HIBADH -1.54 RNASE11 -9.38
HSPA9 5.0 ± 3.2 RNASE11 1.64 HNRNPF 2.63 SEMG2 -5.53
HSPB1 -2.48 RNPEPL1 -1.93 HSP90B1 1.57 SEPT1 -3.58
HSPD1 3.4 ± 0.9 RRAS2 -10.1 HSPA4 -2.48 SERPINB5 -6.06
IFT74 1.9 ± 0.2 SACM1L 3.23 HSPA5 2.14 SIKE1 -3.3 ± 1.3
IGBP1 -5.6 SERPINB5 -3.59 HSPB1 -3.42 ST3GAL4 -2.79
KRT1 -2.42 SRSF9 2.37 HSPD1 4.31 TBCC -3.7 ± 1.5
KRT13 -4.38 TBCC -12.07 ILI2A -2.6 TFB1M -4.55
KRT15 -6.2 ± 1.4 TPRG1 -2.02 KIAA1524 11.9 TRAP1 2.73
KRT17 -2.37 YWHAE -3.29 KRT15 -9.1 ± 2.5 TUBA1B 2.51
KRT18 4.0 ± 1.3 YWHAQ -2.97 KRT17 -7.7 ± 1.8 TUBA1B -2.11
KRT5 -11.6 ± 3.0    KRT2 -5.14 TUBBA2A 3.28
KRT6A -1.86    KRT24 -3.75 UCHL5 -2.68
KRT6B -3.5 ± 0.3    KRT5 -5.35 VPS39 -1.97
KRT83 -2.5    KRT6A -4.0 ± 1.7 YWHAZ -4.5 ± 0.5
LRPPRC 6.2 ± 1.2    LCMT1 -1.58   
  1. Fold-change of proteins identified multiple times is indicated with the S.E.M. and the highest p-value associated with any of the spots. Proteins indicated in bold are up-regulated in 184A1 in comparison with both tumor cell lines. Proteins indicated in bold and italicized are up-regulated in both tumor cell lines in comparison with 184A1
  2. a A positive fold change indicates greater expression in the cancer cells line while a negative fold change indicates a greater expression in 184A1