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Table 1 List of unique proteins that were differentially expressed and formed the dataset for IPA analysis are listed along with the associated fold-change and p-value.

From: Protein-based identification of quantitative trait loci associated with malignant transformation in two HER2+ cellular models of breast cancer

BT-474 versus 184A1

SKBR3 versus 184A1

Gene Symbol

Fold change a

Gene Symbol

Fold Change a

Gene Symbol

Fold change a

Gene Symbol

Fold change a

ACTB

1.9 ± 0.1

LYN

1.62

AKT2

-3.14

LMNA

-2.6

ACTN4

-3.54

MCF2L

2

ALDH2

-1.72

LMNB1

1.98

ACTRT1

-3.75

NDE1

2.33

ANXA5

-6.5

MAP3K7

-4.95

ADSL

-2.58

P4HB

2.9 ± 1.1

ANXA6

1.73

MPP2

2.37

ALCAM

-21.5

PCYT1B

-3.45

APOA1

-2.71

MRPS35

5.18

ALDH2

-2.63

PDE4D

2.45

ATP5B

3.03

NME5

-6.4

ANXA5

-20.5 ± 141

PDE4D

-2.94

ATP5B

-3.2 ± 0.6

NME7

-6.4

ANXA8L2

-4.24

PHB

-2

BPNT1

-2.59

NQO2

-5.83

BCAR3

4.25

PIH1D1

-2.46

CAPN11

3.52

OPA1

-3.06

BID

-3.19

PMM2

2.74

CMPK1

-2.56

P4HB

2.55

C10orf88

-3.28

POLR3E

-2.12

CTNNA3

-3.46

PAF1

-1.97

CAPZB

-2.05

PPFIBP1

2.23

EEF2K

6.03

POLI

-2.11

CDKN2A

3.22

PPM1B

2.99

EIF2S1

-3.89

PPFIBP1

4.18

CSK

-9.11

PRDX2

-5.03

EIF2S2

4.32

PPP1CC

8.87

DPYSL4

1.66

PRPSAP2

-2.87

EIF3I

-3.89

PRDX6

3.21

EEFIG

-2.73

PSMB1

1.76

EVC

10.12

PRKAR2A

-19.47

EIF2B3

-3.95

PSMC2

-5.3 ± 2.5

FAM102B

2.08

PRPS1

-5.46

FSTL1

-7.6

PSMC4

-7.19

GDI2

-2.31

PRPSAP2

-2.31

GNA14

-3.1

PSME1

-2.2 ± 0.6

GNB1L

-6.1

PSMA3

-3.25

GSTP1

-45.37

PTER

-6.49

GOLGA8F

4.17

PSMB8

-3.7

HIBADH

-2.86

RAB27B

-1.83

GRK4

-2.8 ± 0.4

RAB37

-2.17

HORMAD1

-1.63

RAB37

-2.9 ± 0.4

GSTP1

-22.92

RABIL1

-3.01

HSPA1L

-3.53

RAB3A

3.45

GTF3C4

3.69

RMND1

-3.13

HSPA5

2.21

RGN

-1.62

HIBADH

-1.54

RNASE11

-9.38

HSPA9

5.0 ± 3.2

RNASE11

1.64

HNRNPF

2.63

SEMG2

-5.53

HSPB1

-2.48

RNPEPL1

-1.93

HSP90B1

1.57

SEPT1

-3.58

HSPD1

3.4 ± 0.9

RRAS2

-10.1

HSPA4

-2.48

SERPINB5

-6.06

IFT74

1.9 ± 0.2

SACM1L

3.23

HSPA5

2.14

SIKE1

-3.3 ± 1.3

IGBP1

-5.6

SERPINB5

-3.59

HSPB1

-3.42

ST3GAL4

-2.79

KRT1

-2.42

SRSF9

2.37

HSPD1

4.31

TBCC

-3.7 ± 1.5

KRT13

-4.38

TBCC

-12.07

ILI2A

-2.6

TFB1M

-4.55

KRT15

-6.2 ± 1.4

TPRG1

-2.02

KIAA1524

11.9

TRAP1

2.73

KRT17

-2.37

YWHAE

-3.29

KRT15

-9.1 ± 2.5

TUBA1B

2.51

KRT18

4.0 ± 1.3

YWHAQ

-2.97

KRT17

-7.7 ± 1.8

TUBA1B

-2.11

KRT5

-11.6 ± 3.0

  

KRT2

-5.14

TUBBA2A

3.28

KRT6A

-1.86

  

KRT24

-3.75

UCHL5

-2.68

KRT6B

-3.5 ± 0.3

  

KRT5

-5.35

VPS39

-1.97

KRT83

-2.5

  

KRT6A

-4.0 ± 1.7

YWHAZ

-4.5 ± 0.5

LRPPRC

6.2 ± 1.2

  

LCMT1

-1.58

  
  1. Fold-change of proteins identified multiple times is indicated with the S.E.M. and the highest p-value associated with any of the spots. Proteins indicated in bold are up-regulated in 184A1 in comparison with both tumor cell lines. Proteins indicated in bold and italicized are up-regulated in both tumor cell lines in comparison with 184A1
  2. a A positive fold change indicates greater expression in the cancer cells line while a negative fold change indicates a greater expression in 184A1