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Table 1 Haematologic and serum biochemistry data of sea lions in the training dataset

From: Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions

Patients with Blood data n = 29
Avg ± S.E.
n = 47
Avg ± S.E.
n = 20
Avg ± S.E.
DAT v. Stranded non-DAT   DAT v. Combined non-DAT
Component DAT Stranded non-DAT Managed non-DAT DAT Fold Change p -value Combined non-DAT DAT Fold Change p -value
WBC 11.8 ± 0.5 (n = 29) 19.6 ± 1.6 (n = 42) 6.1 ± 0.6 (n = 20) -1.7 < 0.001* 15.3 ± 1.3 (n = 62) -1.3 0.329*
RBC 4.9 ± 0.1 (n = 29) 4.3 ± 0.1 (n = 42) 4.4 ± 0.1 (n = 20) 1.1 < 0.001* 4.3 ± 0.1 (n = 62) 1.1 < 0.001*
HGB 17.4 ± 0.5 (n = 29) 15.0 ± 0.4 (n = 42) 15.9 ± 0.5 (n = 20) 1.2 < 0.001* 15.3 ± 0.3 (n = 62) 1.1 < 0.001*
HCT 51.0 ± 1.4 (n = 29) 43.9 ± 1.1 (n = 42) 45.9 ± 1.5 (n = 20) 1.2 < 0.001* 44.5 ± 0.9 (n = 62) 1.1 < 0.001*
MCV 97 ± 4.5 (n = 29) 103 ± 0.8 (n = 42) 104 ± 1.8 (n = 20) -1.1 0.686* 103 ± 0.8 (n = 62) -1.1 0.749*
MCH 35 ± 0.3 (n = 29) 35 ± 0.3 (n = 42) 36 ± 0.7 (n = 20) 1.0 0.930* 35 ± 0.3 (n = 62) 1.0 0.482
MCHC 34 ± 0.2 (n = 29) 34 ± 0.2 (n = 42) 35 ± 0.2 (n = 20) 1.0 0.582* 34 ± 0.1 (n = 62) 1.0 0.502
PLT 428 ± 28 (n = 29) 414 ± 24 (n = 42) 358 ± 24 (n = 20) 1.0 0.701 396 ± 18.0 (n = 62) 1.1 0.323
RDW 15.8 ± 0.1 (n = 20) 16.2 ± 0.2 (n = 32) 15.3 ± 0.4 (n = 20) 1.0 0.054* 15.9 ± 0.2 (n = 52) 1.0 0.865*
MPV 7.7 ± 0.2 (n = 19) 8.1 ± 0.2 (n = 32) 8.7 ± 0.2 (n = 20) -1.1 0.072 8.4 ± 0.1 (n = 52) -1.1 0.007
Segs 6136 ± 173 (n = 29) 6072 ± 345 (n = 47) 3657 ± 367 (n = 20) 1.0 0.045* 5351 ± 297 (n = 67) 1.1 0.801*
Bands 109 ± 44 (n = 29) 311 ± 80 (n = 47) 13 ± 13 (n = 20) -2.9 0.002* 222 ± 58 (n = 67) -2.0 0.075*
Lymphs 1429 ± 102 (n = 29) 1123 ± 131 (n = 47) 1818 ± 232 (n = 20) 1.3 0.008* 1331 ± 121 (n = 67) 1.1 0.097*
Monos 231 ± 39 (n = 29) 97 ± 18 (n = 47) 389 ± 86 (n = 20) 2.4 < 0.001* 184 ± 33 (n = 67) 1.3 0.079*
Eosin 868 ± 115 (n = 29) 247 ± 59 (n = 47) 214 ± 62 (n = 20) 3.5 < 0.001* 237 ± 45 (n = 67) 3.7 < 0.001*
Na 148 ± 0.9 (n = 28) 156 ± 1.6 (n = 46) 149 ± 0.5 (n = 20) -1.1 < 0.001* 154 ± 1.2 (n = 66) -1.0 < 0.001*
K 4.7 ± 0.09 (n = 28) 4.3 ± 0.10 (n = 47) 4.3 ± 0.10 (n = 20) 1.1 0.026 4.3 ± 0.08 (n = 67) 1.1 0.012
Cl 109 ± 0.7 (n = 28) 119 ± 1.6 (n = 47) 108 ± 0.8 (n = 20) -1.1 < 0.001* 115 ± 1.3 (n = 67) -1.1 0.002*
BUN 21 ± 2.9 (n = 28) 100 ± 15.7 (n = 47) 26 ± 1.3 (n = 20) -4.8 < 0.001* 78 ± 11.7 (n = 67) -3.7 < 0.001*
Creatinine 0.7 ± 0.04 (n = 28) 3.1 ± 0.73 (n = 47) 1.1 ± 0.08 (n = 20) -4.4 0.260* 2.5 ± 0.52 (n = 67) -3.6 0.016*
Glucose 108 ± 4.9 (n = 28) 104 ± 4.0 (n = 47) 125 ± 5.2 (n = 20) 1.0 0.948* 110 ± 3.4 (n = 67) 1.0 0.394*
Ca 8.3 ± 0.12 (n = 27) 8.0 ± 0.13 (n = 47) 9.6 ± 0.12 (n = 20) 1.0 0.091* 8.5 ± 0.14 (n = 67) 1.0 0.405
P 5.1 ± 0.3 (n = 28) 8.0 ± 0.5 (n = 47) 5.7 ± 0.3 (n = 20) -1.6 < 0.001* 7.3 ± 0.4 (n = 67) -1.4 < 0.001*
Total Protein 7.8 ± 0.15 (n = 28) 7.8 ± 0.18 (n = 47) 7.3 ± 0.23 (n = 20) 1.0 0.771* 7.6 ± 0.14 (n = 67) 1.0 0.213*
Albumin 3.0 ± 0.11 (n = 28) 2.4 ± 0.08 (n = 47) 3.4 ± 0.05 (n = 19) 1.3 < 0.001 2.7 ± 0.08 (n = 66) 1.1 0.370
Bilirubin Total 0.5 ± 0.07 (n = 28) 0.7 ± 0.18 (n = 47) 0.2 ± 0.03 (n = 20) -1.4 0.774* 0.5 ± 0.13 (n = 67) 1.0 0.038*
GGT 116 ± 11 (n = 27) 217 ± 25 (n = 47) 67 ± 7 (n = 20) -1.9 < 0.001* 172 ± 20 (n = 67) -1.5 0.232*
AST (SGOT) 65 ± 12 (n = 28) 62 ± 11 (n = 46) 21 ± 2 (n = 20) 1.0 0.438* 49 ± 8 (n = 66) 1.3 0.045*
ALT (SGPT) 88 ± 13 (n = 28) 74 ± 8 (n = 47) 38 ± 3 (n = 20) 1.2 0.095* 63 ± 6 (n = 67) 1.4 0.002*
Alkaline Phosphatase 59 ± 23 (n = 27) 50 ± 10 (n = 47) 98 ± 9 (n = 20) 1.2 0.796* 64 ± 8 (n = 67) -1.1 0.081*
Fe 86 ± 7 (n = 24) 94 ± 6 (n = 46) 115 ± 8 (n = 20) -1.1 0.470 100 ± 5 (n = 66) -1.2 0.150
Cholesterol 172 ± 9 (n = 28) 178 ± 10 (n = 47) 334 ± 18 (n = 20) 1.0 0.827* 224 ± 13 (n = 67) -1.3 0.058*
Triglycerides 52 ± 4 (n = 28) 191 ± 35 (n = 47) 31 ± 4 (n = 20) -3.7 0.003* 143 ± 26 (n = 67) -2.8 0.493*
Mg 1.9 ± 0.07 (n = 23) 2.5 ± 0.17 (n = 44) 2.6 (n = 1) -1.3 0.019* 2.5 ± 0.17 (n = 45) -1.3 0.014*
Creatine Kinase 1881 ± 417 (n = 27) 1434 ± 571 (n = 46) 341 ± 101 (n = 20) 1.3 0.070* 1103 ± 403 (n = 66) 1.7 0.003*
BUN/Cr Ratio 30 ± 4 (n = 28) 55 ± 6 (n = 47) 29 ± 5 (n = 20) -1.8 < 0.001* 47 ± 5 (n = 67) -1.6 0.002*
Na/K Ratio 32 ± 0.7 (n = 28) 36 ± 1.4 (n = 47) 35 ± 0.7 (n = 20) -1.1 0.002* 36 ± 1.0 (n = 67) -1.1 < 0.001*
SDH (Sorbitol Dehydrogenase) 21 ± 4 (n = 20) 30 ± 4 (n = 39) - -1.4 0.016* n.a. n.a. n.a.
  1. A T-test (or rank sum test if distribution was non-normal, indicated by '*') was used to compare blood chemistry values between groups