Table 1 Haematologic and serum biochemistry data of sea lions in the training dataset

Component

DAT

Stranded non-DAT

Managed non-DAT

DAT Fold Change

p -value

Combined non-DAT

DAT Fold Change

p -value

WBC

11.8 ± 0.5 (n = 29)

19.6 ± 1.6 (n = 42)

6.1 ± 0.6 (n = 20)

-1.7

< 0.001*

15.3 ± 1.3 (n = 62)

-1.3

0.329*

RBC

4.9 ± 0.1 (n = 29)

4.3 ± 0.1 (n = 42)

4.4 ± 0.1 (n = 20)

1.1

< 0.001*

4.3 ± 0.1 (n = 62)

1.1

< 0.001*

HGB

17.4 ± 0.5 (n = 29)

15.0 ± 0.4 (n = 42)

15.9 ± 0.5 (n = 20)

1.2

< 0.001*

15.3 ± 0.3 (n = 62)

1.1

< 0.001*

HCT

51.0 ± 1.4 (n = 29)

43.9 ± 1.1 (n = 42)

45.9 ± 1.5 (n = 20)

1.2

< 0.001*

44.5 ± 0.9 (n = 62)

1.1

< 0.001*

MCV

97 ± 4.5 (n = 29)

103 ± 0.8 (n = 42)

104 ± 1.8 (n = 20)

-1.1

0.686*

103 ± 0.8 (n = 62)

-1.1

0.749*

MCH

35 ± 0.3 (n = 29)

35 ± 0.3 (n = 42)

36 ± 0.7 (n = 20)

1.0

0.930*

35 ± 0.3 (n = 62)

1.0

0.482

MCHC

34 ± 0.2 (n = 29)

34 ± 0.2 (n = 42)

35 ± 0.2 (n = 20)

1.0

0.582*

34 ± 0.1 (n = 62)

1.0

0.502

PLT

428 ± 28 (n = 29)

414 ± 24 (n = 42)

358 ± 24 (n = 20)

1.0

0.701

396 ± 18.0 (n = 62)

1.1

0.323

RDW

15.8 ± 0.1 (n = 20)

16.2 ± 0.2 (n = 32)

15.3 ± 0.4 (n = 20)

1.0

0.054*

15.9 ± 0.2 (n = 52)

1.0

0.865*

MPV

7.7 ± 0.2 (n = 19)

8.1 ± 0.2 (n = 32)

8.7 ± 0.2 (n = 20)

-1.1

0.072

8.4 ± 0.1 (n = 52)

-1.1

0.007

Segs

6136 ± 173 (n = 29)

6072 ± 345 (n = 47)

3657 ± 367 (n = 20)

1.0

0.045*

5351 ± 297 (n = 67)

1.1

0.801*

Bands

109 ± 44 (n = 29)

311 ± 80 (n = 47)

13 ± 13 (n = 20)

-2.9

0.002*

222 ± 58 (n = 67)

-2.0

0.075*

Lymphs

1429 ± 102 (n = 29)

1123 ± 131 (n = 47)

1818 ± 232 (n = 20)

1.3

0.008*

1331 ± 121 (n = 67)

1.1

0.097*

Monos

231 ± 39 (n = 29)

97 ± 18 (n = 47)

389 ± 86 (n = 20)

2.4

< 0.001*

184 ± 33 (n = 67)

1.3

0.079*

Eosin

868 ± 115 (n = 29)

247 ± 59 (n = 47)

214 ± 62 (n = 20)

3.5

< 0.001*

237 ± 45 (n = 67)

3.7

< 0.001*

Na

148 ± 0.9 (n = 28)

156 ± 1.6 (n = 46)

149 ± 0.5 (n = 20)

-1.1

< 0.001*

154 ± 1.2 (n = 66)

-1.0

< 0.001*

K

4.7 ± 0.09 (n = 28)

4.3 ± 0.10 (n = 47)

4.3 ± 0.10 (n = 20)

1.1

0.026

4.3 ± 0.08 (n = 67)

1.1

0.012

Cl

109 ± 0.7 (n = 28)

119 ± 1.6 (n = 47)

108 ± 0.8 (n = 20)

-1.1

< 0.001*

115 ± 1.3 (n = 67)

-1.1

0.002*

BUN

21 ± 2.9 (n = 28)

100 ± 15.7 (n = 47)

26 ± 1.3 (n = 20)

-4.8

< 0.001*

78 ± 11.7 (n = 67)

-3.7

< 0.001*

Creatinine

0.7 ± 0.04 (n = 28)

3.1 ± 0.73 (n = 47)

1.1 ± 0.08 (n = 20)

-4.4

0.260*

2.5 ± 0.52 (n = 67)

-3.6

0.016*

Glucose

108 ± 4.9 (n = 28)

104 ± 4.0 (n = 47)

125 ± 5.2 (n = 20)

1.0

0.948*

110 ± 3.4 (n = 67)

1.0

0.394*

Ca

8.3 ± 0.12 (n = 27)

8.0 ± 0.13 (n = 47)

9.6 ± 0.12 (n = 20)

1.0

0.091*

8.5 ± 0.14 (n = 67)

1.0

0.405

P

5.1 ± 0.3 (n = 28)

8.0 ± 0.5 (n = 47)

5.7 ± 0.3 (n = 20)

-1.6

< 0.001*

7.3 ± 0.4 (n = 67)

-1.4

< 0.001*

Total Protein

7.8 ± 0.15 (n = 28)

7.8 ± 0.18 (n = 47)

7.3 ± 0.23 (n = 20)

1.0

0.771*

7.6 ± 0.14 (n = 67)

1.0

0.213*

Albumin

3.0 ± 0.11 (n = 28)

2.4 ± 0.08 (n = 47)

3.4 ± 0.05 (n = 19)

1.3

< 0.001

2.7 ± 0.08 (n = 66)

1.1

0.370

Bilirubin Total

0.5 ± 0.07 (n = 28)

0.7 ± 0.18 (n = 47)

0.2 ± 0.03 (n = 20)

-1.4

0.774*

0.5 ± 0.13 (n = 67)

1.0

0.038*

GGT

116 ± 11 (n = 27)

217 ± 25 (n = 47)

67 ± 7 (n = 20)

-1.9

< 0.001*

172 ± 20 (n = 67)

-1.5

0.232*

AST (SGOT)

65 ± 12 (n = 28)

62 ± 11 (n = 46)

21 ± 2 (n = 20)

1.0

0.438*

49 ± 8 (n = 66)

1.3

0.045*

ALT (SGPT)

88 ± 13 (n = 28)

74 ± 8 (n = 47)

38 ± 3 (n = 20)

1.2

0.095*

63 ± 6 (n = 67)

1.4

0.002*

Alkaline Phosphatase

59 ± 23 (n = 27)

50 ± 10 (n = 47)

98 ± 9 (n = 20)

1.2

0.796*

64 ± 8 (n = 67)

-1.1

0.081*

Fe

86 ± 7 (n = 24)

94 ± 6 (n = 46)

115 ± 8 (n = 20)

-1.1

0.470

100 ± 5 (n = 66)

-1.2

0.150

Cholesterol

172 ± 9 (n = 28)

178 ± 10 (n = 47)

334 ± 18 (n = 20)

1.0

0.827*

224 ± 13 (n = 67)

-1.3

0.058*

Triglycerides

52 ± 4 (n = 28)

191 ± 35 (n = 47)

31 ± 4 (n = 20)

-3.7

0.003*

143 ± 26 (n = 67)

-2.8

0.493*

Mg

1.9 ± 0.07 (n = 23)

2.5 ± 0.17 (n = 44)

2.6 (n = 1)

-1.3

0.019*

2.5 ± 0.17 (n = 45)

-1.3

0.014*

Creatine Kinase

1881 ± 417 (n = 27)

1434 ± 571 (n = 46)

341 ± 101 (n = 20)

1.3

0.070*

1103 ± 403 (n = 66)

1.7

0.003*

BUN/Cr Ratio

30 ± 4 (n = 28)

55 ± 6 (n = 47)

29 ± 5 (n = 20)

-1.8

< 0.001*

47 ± 5 (n = 67)

-1.6

0.002*

Na/K Ratio

32 ± 0.7 (n = 28)

36 ± 1.4 (n = 47)

35 ± 0.7 (n = 20)

-1.1

0.002*

36 ± 1.0 (n = 67)

-1.1

< 0.001*

SDH (Sorbitol Dehydrogenase)

21 ± 4 (n = 20)

30 ± 4 (n = 39)

-

-1.4

0.016*

n.a.

n.a.

n.a.