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Table 1 Proteome map of differentially expressed proteins in K562 and Lucena cell lines.

From: A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line

Spot N° Identified Protein Fold Change > 2
(Ratio Lucena vs. K562) a
  Structural Proteins  
  INCREASE  
1 L MSN Moesin 2.23
2 L RPSA 33 kDa protein 3.45
3 L ACTB Actin, cytoplasmic 1 2.75
  DECREASE  
1 K LCP1 Plastin-2 - 3.65
  Stress Response/Chaperone  
  INCREASE  
4 L HSP90B1 Endoplasmin precursor 2.22
5 L HSPB1 Heat shock protein beta-1 4.23
6 L HSP90AB1 Heat shock protein HSP 90-beta 3.1
7 L HYOU1 Hypoxia up-regulated protein 1 precursor 3.76
8 L VCP Transitional endoplasmic reticulum ATPase 2.29
  DECREASE  
2 K HSP90AB1 Heat shock protein HSP 90-beta - 4.17
  Nucleic Acid Binding, Synthesis, Stability  
  INCREASE  
9 L AARS Alanyl-tRNA synthetase, cytoplasmic 3.43
10 L RPA3 Replication protein A 14 kDa subunit 2.82
11 L RBM17 Splicing factor 45 2.54
12 L LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial precursor 3.18
  DECREASE  
3 K LSM2 U6 snRNA-associated Sm-like protein LSm2 - 3.23
4 K HNRNPF Heterogeneous nuclear ribonucleoprotein F - 3.01
5 K HNRNPC Isoform C1 of Heterogeneous nuclear ribonucleoproteins C1/C2 - 3.22
  Protein Binding and Synthesis  
  INCREASE  
13 L EIF3K Eukaryotic translation initiation factor 3 subunit K 2.96
  DECREASE  
6 K EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal - 2.48
7 K RPS12 ribosomal protein S12 -3.74
8 K HINT1 Histidine triad nucleotide-binding protein 1 -3.57
  Metabolism  
  INCREASE  
14 L ARG2 Arginase-2, mitochondrial precursor 3.83
15 L COX6B1 Cytochrome c oxidase subunit VIb isoform 1 3.15
16 L CKB Creatine kinase B-type 2.1
  DECREASE  
9 K ATP5B ATP synthase subunit beta, mitochondrial precursor - 2.83
10 K TPI1 Isoform 1 of Triosephosphate isomerase - 3.96
  Signaling Transduction  
  INCREASE  
17 L SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 3.04
18 L TXNDC17 Thioredoxin domain-containing protein 17 2.68
19 L GMFB GMFB protein 2.89
20 L CAPNS1 Calpain small subunit 1 2.37
  DECREASE  
11 K STRAP Serine-threonine kinase receptor-associated protein - 3.22
  Cell cycle/Proliferation  
  INCREASE  
21 L MCM7 Isoform 1 of DNA replication licensing factor MCM7 4.02
22 L S100A11 Protein S100-A11 3.15
  Unknown  
  DECREASE  
12 K C19orf10 UPF0556 protein C19orf10 precursor - 3.12
13 K MTPN Myotrophin - 2.98
14 K C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial - 2.37
  1. a Fold change > 2 in resistance: cell lines have constitutively increased or decreased at least 2.0-fold changes of the given protein. Values expressed by ratio mean: Lucena/K562 (resistance versus responsive)
  2. The corresponding spots on 2DE gels were identified with MS/MS