Skip to main content

Table 1 Proteome map of differentially expressed proteins in K562 and Lucena cell lines.

From: A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line

Spot N°

Identified Protein

Fold Change > 2

(Ratio Lucena vs. K562) a

 

Structural Proteins

 
 

INCREASE

 

1 L

MSN Moesin

2.23

2 L

RPSA 33 kDa protein

3.45

3 L

ACTB Actin, cytoplasmic 1

2.75

 

DECREASE

 

1 K

LCP1 Plastin-2

- 3.65

 

Stress Response/Chaperone

 
 

INCREASE

 

4 L

HSP90B1 Endoplasmin precursor

2.22

5 L

HSPB1 Heat shock protein beta-1

4.23

6 L

HSP90AB1 Heat shock protein HSP 90-beta

3.1

7 L

HYOU1 Hypoxia up-regulated protein 1 precursor

3.76

8 L

VCP Transitional endoplasmic reticulum ATPase

2.29

 

DECREASE

 

2 K

HSP90AB1 Heat shock protein HSP 90-beta

- 4.17

 

Nucleic Acid Binding, Synthesis, Stability

 
 

INCREASE

 

9 L

AARS Alanyl-tRNA synthetase, cytoplasmic

3.43

10 L

RPA3 Replication protein A 14 kDa subunit

2.82

11 L

RBM17 Splicing factor 45

2.54

12 L

LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial precursor

3.18

 

DECREASE

 

3 K

LSM2 U6 snRNA-associated Sm-like protein LSm2

- 3.23

4 K

HNRNPF Heterogeneous nuclear ribonucleoprotein F

- 3.01

5 K

HNRNPC Isoform C1 of Heterogeneous nuclear ribonucleoproteins C1/C2

- 3.22

 

Protein Binding and Synthesis

 
 

INCREASE

 

13 L

EIF3K Eukaryotic translation initiation factor 3 subunit K

2.96

 

DECREASE

 

6 K

EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal

- 2.48

7 K

RPS12 ribosomal protein S12

-3.74

8 K

HINT1 Histidine triad nucleotide-binding protein 1

-3.57

 

Metabolism

 
 

INCREASE

 

14 L

ARG2 Arginase-2, mitochondrial precursor

3.83

15 L

COX6B1 Cytochrome c oxidase subunit VIb isoform 1

3.15

16 L

CKB Creatine kinase B-type

2.1

 

DECREASE

 

9 K

ATP5B ATP synthase subunit beta, mitochondrial precursor

- 2.83

10 K

TPI1 Isoform 1 of Triosephosphate isomerase

- 3.96

 

Signaling Transduction

 
 

INCREASE

 

17 L

SH3BGRL SH3 domain-binding glutamic acid-rich-like protein

3.04

18 L

TXNDC17 Thioredoxin domain-containing protein 17

2.68

19 L

GMFB GMFB protein

2.89

20 L

CAPNS1 Calpain small subunit 1

2.37

 

DECREASE

 

11 K

STRAP Serine-threonine kinase receptor-associated protein

- 3.22

 

Cell cycle/Proliferation

 
 

INCREASE

 

21 L

MCM7 Isoform 1 of DNA replication licensing factor MCM7

4.02

22 L

S100A11 Protein S100-A11

3.15

 

Unknown

 
 

DECREASE

 

12 K

C19orf10 UPF0556 protein C19orf10 precursor

- 3.12

13 K

MTPN Myotrophin

- 2.98

14 K

C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial

- 2.37

  1. a Fold change > 2 in resistance: cell lines have constitutively increased or decreased at least 2.0-fold changes of the given protein. Values expressed by ratio mean: Lucena/K562 (resistance versus responsive)
  2. The corresponding spots on 2DE gels were identified with MS/MS