Skip to main content

Advertisement

Table 4 Most frequent selected peaks in the leave-one-out internal validation (LOO) iterations, with the corresponding chip surface and mass range

From: Proteomic biomarkers predicting lymph node involvement in serum of cervical cancer patients. Limitations of SELDI-TOF MS

  Median m/z value Occurrence* p-value Chip surface Mass range §
Lymph node status
 Negative vs Positive
  2698.945 15 0.023 IMAC Low
  15254.808 14 0.022 IMAC High
  3953.177 13 0.024 CM10 Low
Histological subtype
 Squamous ca. vs Adenoca.
  12802.775 28 0.021 CM10 High
  78632.414 11 0.020 IMAC High
 Squamous ca. vs Adenosquamous ca.
  1532.112 39 0.032 CM10 Low
  1532.166 39 0.032 CM10 Low
  1627.269 39 0.032 IMAC Low
  4783.483 38 0.032 IMAC Low
 Adenoca. vs Adenosquamous ca.
  1531.463 16 0.012 CM10 Low
LVSI
 Negative vs Positive
  1741.204 58 0.008 IMAC Low
  3224.349 13 0.010 CM10 Low
Recurrence
 Negative vs Positive
  94029.326 53 0.021 IMAC High
  97177.269 52 0.018 IMAC High
  78294.986 52 0.027 IMAC High
  2044.703 21 0.031 IMAC Low
  1979.514 15 0.035 IMAC Low
  1. * The number of times the peak was selected within the different LOO iterations.
  2. § Low mass range: <10 kDa; high mass range >10 kDa.
  3. Abbreviations: CM10 = weak cation exchanger array; IMAC = immobilized metal affinity capture array; ca. = carcinoma; LVSI = lymph vascular space involvement.