Figure 6

Rosuvastatin regulates protein expression in a NO-dependent manner. (A) Protein lysates (1 mg) from ECs treated with rosuvastatin (10 μM) alone or with rosuvastatin in the presence of L-NAME (1 mM) for 24 h were subjected to 2-DE. Results are shown by VisPRO staining. Arrows indicate the proteins that were upregulated by rosuvastatin. (B) Each asterisk indicates a protein that was upregulated by rosuvastatin but was suppressed by L-NAME co-treatment. The relative fold change in protein level is shown by spot density as mean ± S.E. from three separate experiments.