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Table 1 Significant changes in alveolar macrophage proteins for Female mice (as compared to KO baseline)

From: Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A

Gel no. Protein name KO 6 hr SP-A
Female
KO 18 hr SP-A
Female
WT
Female
5 Alpha-fetoprotein ↑*
8 Anxa5 protein ↑*
11 Calpain, small subunit 1 ↓*
12 Capping protein (actin filament) muscle Z-line, alpha 2 (CapZ alpha-2) ↓* ↓*
13 Capping protein (actin filament) muscle Z-line, beta isoform a (CapZ beta) ↓*
24 Eno1 protein (Alpha-enolase) ↑*
25 Eukaryotic translation initiation factor 5A ↑*
26 Ezrin ↓*
29 Ferritin light chain 1 ↓*
30 Gamma-actin ↓*
34 Heat shock protein 1, beta (HSP90AB1) ↓* ↓*
35 Heat shock protein 5 precursor (GRP78) ↓*
40 Heme-binding protein ↓* ↓*
41 Heterogeneous nuclear ribonucleoprotein K ↓*
45 Keratin complex 2, basic, gene 8 ↑*
52 Nucleophosmin 1 ↓* ↓*
53 p50b ↓*
55 Prolyl 4-hydroxylase, beta polypeptide precursor ↑* ↑*
56 Proteasome (prosome, macropain) 28 subunit, alpha ↑* ↑*
61 Purine nucleoside phosphorylase ↑* ↑*
64 Rho GDP dissociation inhibitor (GDI) alpha ↑* ↑*
67 Stathmin ↑* ↑*
74 Vacuolar adenosine triphosphatase subunit B ↑*
76 Vimentin ↓*
  Total significant changes 7↓*, 6↑* 5↓*, 4↑* 5↓*, 6↑*
  1. Comparison of mean normalized volumes (see Additional file 3) for proteins from female KO mice to KO 6 hr SP-A, KO 18 hr SP-A, and WT mice. Increased compared to KO(↑), decreased compared to KO(↓), determined to be significant (p < 0.05) by t-test (*). Changes in all proteins are given in Additional file 4 - Table F.