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Table 2 Significant changes in alveolar macrophage proteins from male to female mice in the same group

From: Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A

Gel no. Protein name KO KO 6 hr SP-A KO 18 hr SP-A WT
6 Annexin A2 ↓* UN
7 Annexin A4 ↓*
8 Anxa5 protein ↓*
12 Capping protein (actin filament) muscle Z-line, alpha 2 (CapZ alpha-2) ↓*
15 Chaperonin subunit 2 (beta) (CCT2) ↑*
17 Chitinase 3-like 3 precursor (Ym1) UN ↑* ↑*
20 Chloride intracellular channel 4 (mitochondrial) ↓*
22 Coactosin-like 1 ↓*
33 Guanine deaminase ↑* ↑* ↑* ↑*
34 Heat shock protein 1, beta (HSP90AB1) ↑* ↑*
35 Heat shock protein 5 precursor (GRP78) ↑* ↑*
36 Heat shock protein 65 (HSP60) ↑* ↑*
38 Heat shock protein 90, beta (Grp94), member 1 ↑*
40 Heme-binding protein UN ↓* UN
49 Major vault protein (MVP) ↑* ↑*
50 Microtubule-associated protein, RP/EB family, member 1 ↑* ↑*
55 Prolyl 4-hydroxylase, beta polypeptide precursor ↓*
59 Protein disulfide-isomerase A3 precursor ↑*
60 Protein synthesis initiation factor 4A ↑* ↑*
62 Put. beta-actin (aa 27–375) ↓*
63 Rab GDP dissociation inhibitor beta ↑*
64 Rho GDP dissociation inhibitor (GDI) alpha ↑* ↑*
69 Tropomodulin 3 ↓* ↓*
70 Tropomyosin 3, gamma ↓*
71 Tubulin, beta 5 ↓* ↓*
75 Valosin-containing protein ↑* ↑*
76 Vimentin ↓* ↓*
  Total significant changes 2↓*, 3↑* 4↓*, 2↑* 9↓*, 11↑* 1↓*, 10↑*
  1. Comparison of mean normalized volumes (see Additional file 3) for proteins from male to female mice in the same group (KO, KO 6 hr SP-A, KO 18 hr SP-A, and WT). Higher in female (), lower in female (), unchanged (UN), determined to be significant (p < 0.05) by t-test (*). Changes in all proteins are given in Additional file 5 -Table F.