Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells

Izabela Sokolowska; Cristina Dorobantu; Alisa G Woods; Alina Macovei; Norica Branza-Nichita; Costel C Darie

doi:10.1186/1477-5956-10-47

Proteome Science

Table 2 List with the proteins that were differentially identified by LC-MS/MS analysis of the plasma membranes of undifferentiated (−) and differentiated (+) cells (experiment #2)

From: Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells

	Proteins identified only in (-) cells
Protein Accession #	Protein_description
gi\|458470	carboxylesterase [Homo sapiens]
gi\|62088648	tumor rejection antigen (gp96) 1 variant [Homo sapiens]
gi\|28614	aldolase A [Homo sapiens]
gi\|18645167	Annexin A2 [Homo sapiens]
gi\|31179	enolase [Homo sapiens]
gi\|34707	Manganese superoxide dismutase [Homo sapiens]
gi\|4502013	adenylate kinase 2, mitochondrial isoform a [Homo sapiens]
gi\|178390	aldehyde dehydrogenase [Homo sapiens]
gi\|4504505	peroxisomal multifunctional enzyme type 2 isoform 2 [Homo sapiens]
gi\|4503285	aldo-keto reductase family 1 member C2 isoform 1 [Homo sapiens]
gi\|1723158	dihydrodiol dehydrogenase/bile acid-binding protein [Homo sapiens]
gi\|6009628	brain carboxylesterase hBr3 [Homo sapiens]
gi\|386758	GRP78 precursor [Homo sapiens]
gi\|4507913	wiskott-Aldrich syndrome protein family member
	Proteins identified only in (+) cells
gi\|306891	90kDa heat shock protein [Homo sapiens]
gi\|1633054	Chain A, Cyclophilin A Complexed With Dipeptide Gly-Pro
gi\|4507677	endoplasmin precursor [Homo sapiens]
gi\|75766275	Chain A, Crystal Structure Of Human Cypa Mutant K131a
gi\|61656603	Heat shock protein HSP 90 - alpha 2 [Homo sapiens]
gi\|179930	carboxylesterase [Homo sapiens]
gi\|2981743	Chain A, Secypa Complexed With Hagpia (Pseudo-Symmetric Monomer)
gi\|4757756	annexin A2 isoform 2 [Homo sapiens]
gi\|4826898	profilin-1 [Homo sapiens]
gi\|342350777	Chain A, Human Annexin V With Incorporated Methionine Analogue Azidohomoalanine
gi\|32189394	ATP synthase subunit beta, mitochondrial precursor [Homo sapiens]
gi\|157833780	Chain A, Human Annexin V With Proline Substitution By Thioproline
gi\|53791219	filamin A [Homo sapiens]
gi\|31645	glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens]
gi\|14327942	HSP90B1 protein [Homo sapiens]
gi\|28614	aldolase A [Homo sapiens]
gi\|662841	heat shock protein 27 [Homo sapiens]
gi\|999892	Chain A, Crystal Structure Of Recombinant Human Triosephosphate Isomerase At 2.8 Angstroms
	Resolution.
gi\|35505	pyruvate kinase [Homo sapiens]
gi\|693933	2-phosphopyruvate-hydratase alpha-enolase [Homo sapiens]
gi\|4503483	elongation factor 2 [Homo sapiens]
gi\|5729877	heat shock cognate 71 kDa protein isoform 1 [Homo sapiens]
gi\|4505591	peroxiredoxin-1 [Homo sapiens]
gi\|6525069	tumor necrosis factor type 1 receptor associated protein [Homo sapiens]
gi\|4502101	annexin A1 [Homo sapiens]
gi\|189617	protein PP4-X [Homo sapiens]
gi\|4758012	clathrin heavy chain 1 [Homo sapiens]
gi\|34419635	70kDa heat shock protein 6 [Homo sapiens]
gi\|4507357	transgelin-2 [Homo sapiens]
gi\|577295	KIAA0088 [Homo sapiens]
gi\|35830	ubiquitin activating enzyme E1 [Homo sapiens]
gi\|6470150	BiP protein [Homo sapiens]
gi\|5453790	nicotinamide N-methyltransferase [Homo sapiens]
gi\|5803227	14-3-3 protein theta [Homo sapiens]
gi\|38648667	Fatty acid synthase [Homo sapiens]
gi\|31746	glutathione-insulin transhydrogenase (216 AA) [Homo sapiens]
gi\|1421609	Chain A, X-Ray Structure Of Nm23 Human Nucleoside Diphosphate Kinase B Complexed With
	Gdp At 2 Angstroms Resolution
gi\|438069	thiol-specific antioxidant protein [Homo sapiens]
gi\|61104911	heat shock protein 90Bb [Homo sapiens]
gi\|4758304	protein disulfide-isomerase A4 precursor [Homo sapiens]
gi\|5802974	thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor [Homo sapiens]
gi\|3318841	Chain A, Horf6 A Novel Human Peroxidase Enzyme
gi\|230867	Chain R, Twinning In Crystals Of Human Skeletal Muscle D- Glyceraldehyde-3-Phosphate
gi\|230867	Dehydrogenase
gi\|5031857	L-lactate dehydrogenase A chain isoform 1 [Homo sapiens]
gi\|4507877	vinculin isoform VCL [Homo sapiens]
gi\|1710248	protein disulfide isomerase-related protein 5 [Homo sapiens]
gi\|5031635	cofilin-1 [Homo sapiens]
gi\|83753119	Chain A, Crystal Structure Of Human Full-Length Vinculin (Residues 1- 1066)
gi\|157879202	Chain B, Crystal Structures Of Native And Inhibited Forms Of Human Cathepsin D: Implications
	For Lysosomal Targeting And Drug Design
gi\|74722493	RecName: Full=Putative heat shock protein HSP 90-alpha A4; AltName: Full=Heat shock 90 kDa
gi\|74722493	protein 1 alpha-like 2; AltName: Full=Heat shock protein 90-alpha D
gi\|181250	cyclophilin [Homo sapiens]
gi\|182855	80K-H protein [Homo sapiens]
gi\|37267	transketolase [Homo sapiens]
gi\|1065111	Chain A, High Resolution Solution Nmr Structure Of Mixed Disulfide Intermediate Between
	Mutant Human Thioredoxin And A 13 Residue Peptide Comprising Its Target Site In Human Nfkb
gi\|1477646	plectin [Homo sapiens]
gi\|4507953	14-3-3 protein zeta/delta [Homo sapiens]
gi\|2138314	lysyl hydroxylase isoform 2 [Homo sapiens]
gi\|283807248	Chain A, Crystal Structure Analysis Of W21a Mutant Of Human Gsta1-1 In Complex With
	S-Hexylglutathione
gi\|6005942	transitional endoplasmic reticulum ATPase [Homo sapiens]
gi\|1065322	Chain A, A Surface Mutant (G82r) Of A Human Alpha-Glutathione S- Transferase Shows Decreased
gi\|1065322	Thermal Stability And A New Mode Of Molecular Association In The Crystal
gi\|799177	100 kDa coactivator [Homo sapiens]
gi\|4505753	phosphoglycerate mutase 1 [Homo sapiens]
gi\|5107666	Chain A, Structure Of Importin Beta Bound To The Ibb Domain Of Importin Alpha
gi\|158937236	puromycin-sensitive aminopeptidase [Homo sapiens]
gi\|5825506	fatty acid synthase/estrogen receptor fusion protein [Homo sapiens]
gi\|5257007	beta-cop homolog [Homo sapiens]
gi\|896473	iron-responsive regulatory protein/iron regulatory protein 1 [Homo sapiens]
gi\|34707	Manganese superoxide dismutase [Homo sapiens]
gi\|4506715	40S ribosomal protein S28 [Homo sapiens]
gi\|3212355	Chain A, P11 (S100a10), Ligand Of Annexin Ii
gi\|1065361	Chain A, Human Adp-Ribosylation Factor 1 Complexed With Gdp, Full Length Non-Myristoylated
gi\|159162145	Chain A, Rotamer Strain As A Determinant Of Protein Structural Specificity
gi\|51247357	Chain A, Crystal Structure Of A Multiple Hydrophobic Core Mutant Of Ubiquitin
gi\|215273984	RecName: Full=Putative inactive carboxylesterase 4; AltName: Full=Inactive carboxylesterase 1
gi\|215273984	pseudogene 1; AltName: Full=Placental carboxylesterase 3; Short=PCE-3; Flags: Precursor
gi\|4502013	adenylate kinase 2, mitochondrial isoform a [Homo sapiens]
gi\|5803013	endoplasmic reticulum resident protein 29 isoform 1 precursor [Homo sapiens]
gi\|229532	ubiquitin
gi\|31615803	Chain A, Synthetic Ubiquitin With Fluoro-Leu At 50 And 67
gi\|2627129	polyubiquitin [Homo sapiens]
gi\|6755368	40S ribosomal protein S18 [Mus musculus]
gi\|313103963	Chain D, Structure And Control Of The Actin Regulatory Wave Complex
gi\|6114601	stromal antigen 3, (STAG3) [Homo sapiens]
gi\|4588526	nuclear chloride channel [Homo sapiens]
	Proteins identified in(-) and (+) cells
gi\|32189394	ATP synthase subunit beta, mitochondrial precursor [Homo sapiens]
gi\|31645	glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens]
gi\|1710248	protein disulfide isomerase-related protein 5 [Homo sapiens]
gi\|215273984	RecName: Full=Putative inactive carboxylesterase 4; AltName: Full=Inactive carboxylesterase 1
gi\|215273984	pseudogene 1; AltName: Full=Placental carboxylesterase 3; Short=PCE-3; Flags: Precursor
gi\|4758304	protein disulfide-isomerase A4 precursor [Homo sapiens]
gi\|4505591	peroxiredoxin-1 [Homo sapiens]
gi\|303618	phospholipase C-alpha [Homo sapiens]
gi\|5031857	L-lactate dehydrogenase A chain isoform 1 [Homo sapiens]
gi\|5802974	thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor [Homo sapiens]
gi\|306891	90kDa heat shock protein [Homo sapiens]

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