Table 3 Proteins identified in this work as altered in Osteoarthritis vs Control sera

A1AT

P01009

Alpha-1-antitrypsin

Inhibitor of serine proteases

1.4

0.008

46878

5.37

40047

5.33

151

K. TDTSHHDQDHPTFNK.I

K. ITPNLAEFAFSLYR.Q

K. QINDYVEKGTQGK.I

K. GKWERPFEVK.D

K. DTEEEDFHVDQVTTVK.V

R. LGMFNIQHCK.K

K. LQHLENELTHDIITK.F

K. FLENEDRR.S

K. VFSNGADLSGVTEEAPLK.L

K. FNKPFVFLMIEQNTK.S

FETUA

P02765

Alpha-2-HS-glycoprotein

Negative regulation of bone mineralization

2

0.004

40098

5.43

40098

5.43

102

K. CNLLAEKQYGFCK.A

R. HTFMGVVSLGSPSGEVSHPR.K

ANGT

P01019

Angiotensinogen

Essential component of the renin-angiotensin system (RAS)

1.3

0.001

53406

5.87

40056

5.48

28

K. ANAGKPKDPTFIPAPIQAK.T

APOA1

P02647

Apolipoprotein A-I

Cholesterol metabolism

2.2

0.013

30759

5.56

31221

5.43

271

K. DSGRDYVSQFEGSALGK.Q

K. LLDNWDSVTSTFSK.L

K. LLDNWDSVTSTFSKLR.E

K. VQPYLDDFQKK.W

K. KWQEEMELYR.Q

K. WQEEMELYR.Q

K. VEPLRAELQEGAR.Q

K. LSPLGEEMRDR.A

R. THLAPYSDELR.Q

R. THLAPYSDELRQR.L

K. ATEHLSTLSEKAKPALEDLR.Q

K. AKPALEDLR.Q

APOA2

P02652

Apolipoprotein A-II

Lipid transport

0.7

0.003

11282

6.26

11064

5.23

82

K. VKSPELQAEAK.S

K. SPELQAEAK.S

K. SKEQLTPLIK.K

APOA4

P06727

Apolipoprotein A-IV

Lipid transport

0.6

0.005

45371

5.28

37738

5.47

37

K. LVPFATELHER.L

R. LEPYADQLR.T

R. TQVNTQAEQLRR.Q

R. QLTPYAQR.M

K. IDQNVEELKGR.L

R. ISASAEELRQR.L

R. LAPLAEDVR.G

R. LAPLAEDVRGNLR.G

K. SLAELGGHLDQQVEEFR.R

K. SLAELGGHLDQQVEEFRR.R

R. RVEPYGENFNK.A

K. ALVQQMEQLR.Q

APOC3

P02656

Apolipoprotein C-III

Lipid degradation and transport

0.8

0.014

10846

5.23

13922

5.16

149

K. TAKDALSSVQESQVAQQAR.G

K. DALSSVQESQVAQQAR.G

HPT

P00738

Haptoglobin (β chain)

Cellular iron ion homeostasis

2

0.007

45861

6.13

35377

5.74

90

K. GSFPWQAK.M

R. NANFKFTDHLK.Y

K. YVMLPVADQDQCIR.H

K. SPVGVQPILNEHTFCAGMSK.Y

HPT

P00738

Haptoglobin (α 1 chain)

Cellular iron ion homeostasis

1.4

0.006

45861

6.13

19281

5.98

68

R. YQCKNYYK.L

K. LRTEGDGVYTLNNEK.Q

K. AVGDKLPECEAVCGKPK.N

HPT

P00738

Haptoglobin (α 2 chain)

Cellular iron ion homeostasis

0.5

0.0002

45861

6.13

28110

5.97

135

R. TEGDGVYTLNDKK.Q

K. LRTEGDGVYTLNNEK.Q

K. AVGDKLPECEAVCGKPK.N

K. AVGDKLPECEAVCGKPK.N

HBB

P68871

Hemoglobin subunit beta

Involved in oxygen transport from the lung to peripheral tissues

1.6

0.014

16102

6.75

16102

6.75

43

R. LLVVYPWTQR.F

IGKC

P01834

Ig kappa chain C region

Immune response

0.6

0.003

11773

5.58

33273

6.42

107

-. TVAAPSVFIFPPSDEQLK.S

K. SGTASVVCLLNNFYPR.E

LAC2

P0CG05

Ig lambda-2 chain C regions

Complement activation, classical pathway

0.6

0.003

11458

6.92

33273

6.42

72

K. AAPSVTLFPPSSEELQANK.A

K. QSNNKYAASSYLSLTPEQWK.S

R. SYSCQVTHEGSTVEK.T

R. SYSCQVTHEGSTVEKTVAPTECS.-

A2GL

P02750

Leucine-rich alpha-2-glycoprotein

Protein binding (secreted)

1.5

0.005

38382

6.45

38507

5.47

88

R. YLFLNGNKLAR.V

R. VAAGAFQGLR.Q

R. CAGPEAVKGQTLLAVAK.S

SAA

P02735

Serum amyloid A protein

Acute-phase response

0.8

0.014

13581

6.28

15299

6.53

52

R.EANYIGSDKYFHAR.G

R.FFGHGAEDSLADQAANEWGR.S

TTHY

P02766

Transthyretin

Thyroid hormone-binding protein

2.2

0.022

15991

5.52

28287

6.3

136

R.KAADDTWEPFASGK.T

K.AADDTWEPFASGK.T