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Table 4 Association of serum PDGF-BB and Prolactin levels (in ng/ml) with clinical parameters

From: An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes

  PDGF-BB (ng/ml) Prolactin (ng/ml)
Disease:   
PSP/CBS (n = 38) a 8.7 (2.7-12.6) 3.4 (0.3-41.2)
 MSA (n = 31) a 8.4 (2.9-11.6) 3.3 (0.1-74.1)
 PD (n = 117) a 6.9 (3.0-12.7) 2.3 (0.0-35.1)
 Controls (n = 99) a 5.9 (2.0-10.8) 3.7 (0.5-37.5)
  p = 4x10-7 b p = 3x10-7 b
Females (n = 132) a 6.7 (2.4-12.7) 3.1 (0.0-74.1)
Males (n = 153) a 6.8 (2.0-12.0) 3.3 (0.0-37.4)
  p = ns c p = ns c
Age, y R = 0.006 R = −0.040
  p = ns d p = ns d
Duration, y R = −0.183 R = −0.226
  p = ns d p = ns d
Hoehn&Yahr R = 0.105 R = 0.217
  p = ns e p = 0.02 e
Dementia (n = 31) a 8.3 (4.2-12.6) 3.1 (0.0-35.1)
No Dementia (n = 148) a 7.1 (2.6-12.7) 2.7 (0.0-74.1)
  p = 0.038 c p = ns c
Parkinson treatment:   
 None (n = 48) a 6.5 (2.0-12.7) 3.6 (0.2-37.5)
 LD (n = 48) a 7.4 (2.7-12.6) 4.0 (0.0-74.1)
 DA (n = 8) a 6.6 (3.7-8.6) 0.0 (0.0-3.1)
 MAO-B Inh. (n = 8) a 8.1 (5.5-11.4) 2.8 (1.7-4.7)
 LD + DA (n = 48) a 6.1 (2.9-11.4) 0.2 (0.0-33.2)
 LD + MAO-B Inh. (n = 12) a 10.3 (5.0-11.7) 9.4 (0.3-41.2)
 LD + DA + MAO-B Inh. (n = 7) a 6.9 (5.6-10.4) 0.3 (0.0-19.9)
  p = 0.002 b p = 7x10-13 b
  1. a Data are shown as median (range). Associations were statistically analyzed by b Kruskal Wallis test, c Mann–Whitney U tests, d linear regressions and e Spearman’s correlations. P-values were corrected for 7 comparisons by Bonferroni’s correction for multiple comparisons.
  2. Abbreviations: ns = not statistically significant, R = correlation coefficient, LD = patients treated with levodopa, DA = patients treated with dopmaine agonists, MAO-B Inh. = patients treated with monoamine oxidase inhibitors.