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Table 4 Association of serum PDGF-BB and Prolactin levels (in ng/ml) with clinical parameters

From: An antibody microarray analysis of serum cytokines in neurodegenerative Parkinsonian syndromes

 

PDGF-BB (ng/ml)

Prolactin (ng/ml)

Disease:

  

PSP/CBS (n = 38) a

8.7 (2.7-12.6)

3.4 (0.3-41.2)

 MSA (n = 31) a

8.4 (2.9-11.6)

3.3 (0.1-74.1)

 PD (n = 117) a

6.9 (3.0-12.7)

2.3 (0.0-35.1)

 Controls (n = 99) a

5.9 (2.0-10.8)

3.7 (0.5-37.5)

 

p = 4x10-7 b

p = 3x10-7 b

Females (n = 132) a

6.7 (2.4-12.7)

3.1 (0.0-74.1)

Males (n = 153) a

6.8 (2.0-12.0)

3.3 (0.0-37.4)

 

p = ns c

p = ns c

Age, y

R = 0.006

R = −0.040

 

p = ns d

p = ns d

Duration, y

R = −0.183

R = −0.226

 

p = ns d

p = ns d

Hoehn&Yahr

R = 0.105

R = 0.217

 

p = ns e

p = 0.02 e

Dementia (n = 31) a

8.3 (4.2-12.6)

3.1 (0.0-35.1)

No Dementia (n = 148) a

7.1 (2.6-12.7)

2.7 (0.0-74.1)

 

p = 0.038 c

p = ns c

Parkinson treatment:

  

 None (n = 48) a

6.5 (2.0-12.7)

3.6 (0.2-37.5)

 LD (n = 48) a

7.4 (2.7-12.6)

4.0 (0.0-74.1)

 DA (n = 8) a

6.6 (3.7-8.6)

0.0 (0.0-3.1)

 MAO-B Inh. (n = 8) a

8.1 (5.5-11.4)

2.8 (1.7-4.7)

 LD + DA (n = 48) a

6.1 (2.9-11.4)

0.2 (0.0-33.2)

 LD + MAO-B Inh. (n = 12) a

10.3 (5.0-11.7)

9.4 (0.3-41.2)

 LD + DA + MAO-B Inh. (n = 7) a

6.9 (5.6-10.4)

0.3 (0.0-19.9)

 

p = 0.002 b

p = 7x10-13 b

  1. a Data are shown as median (range). Associations were statistically analyzed by b Kruskal Wallis test, c Mann–Whitney U tests, d linear regressions and e Spearman’s correlations. P-values were corrected for 7 comparisons by Bonferroni’s correction for multiple comparisons.
  2. Abbreviations: ns = not statistically significant, R = correlation coefficient, LD = patients treated with levodopa, DA = patients treated with dopmaine agonists, MAO-B Inh. = patients treated with monoamine oxidase inhibitors.