A framework for personalized medicine: prediction of drug sensitivity in cancer by proteomic profiling

Table 2 Accuracy of sensitivity prediction for 24 drugs with 20 selected features

Drug Name	SVML	SVMP	SVMR	LR	RF	NBC	TAN	ANBC
8-aminoadenosine	68.89	68.89	68.89	71.11	55.56	91.11	93.33	93.33
8-Cl-adenosine	51.11	55.56	55.56	55.56	64.44	93.33	86.67	92.89
Carboplatin	71.11	73.33	73.33	62.22	71.11	86.67	80.00	88.00
Chloroquine	70.45	65.91	65.91	54.55	70.45	97.73	88.64	95.91
Cisplatin	79.07	65.11	65.11	58.14	81.40	90.70	93.02	91.63
Cyclopamine	28.89	40.00	17.78	51.11	42.22	84.44	80.00	86.67
Diazonamide	80.49	80.49	80.49	60.98	70.74	92.68	90.24	90.73
Docetaxel	90.24	90.24	90.24	78.05	90.24	100	100	100
Doxorubicin	41.30	56.52	56.52	43.48	58.70	89.13	76.09	88.70
Erlotinib	86.05	86.05	86.05	88.37	90.70	88.37	97.67	88.37
Etoposide	55.81	62.79	62.79	53.49	65.12	95.35	90.70	94.88
Gefitinib	90.00	90.00	90.00	90.00	90.00	95.00	65.00	95.00
Gemcitabine	81.81	81.81	81.81	61.36	77.27	100	100	100
Gemcitabine/Cisplatin	73.81	71.43	71.43	61.90	66.67	95.24	65.24	91.43
Irinotecan	47.50	55.00	55.00	50.00	40.00	92.50	90.00	92.50
Orexin	83.33	83.33	83.33	77.78	83.33	100	100	100
Paclitaxel	85.11	85.11	85.11	61.70	85.11	100	93.62	100
Paclitaxel/Carboplatin	90.20	90.20	90.20	82.35	90.20	98.04	98.04	98.04
Peloruside A	80.95	80.95	80.95	66.67	80.95	92.86	92.86	95.24
Pemetrexed	59.09	52.27	52.27	68.18	65.91	93.18	81.82	93.18
Pemetrexed/Cisplatin	61.90	61.90	61.90	57.14	47.62	83.33	85.71	90.00
Smac Mimetic	84.62	84.62	84.62	66.67	82.05	97.44	92.31	97.44
Sorafenib	87.23	87.23	87.23	78.72	85.11	97.87	91.49	97.87
Vinorelbine	79.07	79.07	79.07	51.16	76.74	90.70	93.02	90.70
Average	72.00	72.83	71.90	64.61	72.15	93.57	91.06	93.85

ISSN: 1477-5956