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Figure 7 | Proteome Science

Figure 7

From: Identifying transcription factors and microRNAs as key regulators of pathways using Bayesian inference on known pathway structures

Figure 7

Analysis of the cell cycle pathway. Selected nodes from the merged cell cycle pathway. The original nodes in the pathway are in green. The TFs (squares) and microRNAs (triangles) that target them are also included. The differentially expressed gene CCND1 is marked in red and the TF TFE3 (putative regulator) is in light blue According to the pathway definition in KEGG, SMAD3 promotes the expression of CDKN2B and CDKN2B inhibits CCND1 and CDK4. According to our analysis, CCND1 was over-expressed in ER+ samples.

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