Table 2 A summary of the names, modification sizes, and modification sites of all the in vivo PTMs, as well as the number of spectra, unique peptides, and proteins with in vivo PTMs

Oxidation or Hydroxylation

MODa

16

CDKNPRY

204

105

40

PEAKS 6

15.99

DKNPRY

224

139

71

Methylation

MODa

14

CDEHKNSQRT

106

58

27

PEAKS 6

14.02

DEILNT, C-term, N-term

157

160

99

Dehydration

MODa

−18

ST

26

19

14

PEAKS 6

−18.01

STY

102

81

67

Dihydroxy

MODa

32

CLMPT

29

1

10

PEAKS 6

31.99

KPRY

32

48

30

Phosphorylation

MODa

80

DS

20

8

2

PEAKS 6

79.97

ST

192

154

57

Acetylation

MODa

42

STM(Protein N-term)

7

5

5

PEAKS 6

42.01

CST, Protein N-term

39

41

46

Hydroxymethyl

MODa

30

N

3

1

1

Pyrophosphorylation

160

S

16

2

1

Lysine oxidation to aminoadipic semialdehyde

−1

K

12

6

6

Deamidation

1

R

7

4

4

Didehydro

−2

SY

6

1

1

HexNAc

PEAKS 6

203.08

NST

141

19

43

Carboxylation

43.99

E

10

6

7

Persulfide

31.97

D

7

6

8

Hexose

162.05

T, N-term

4

14

14