Table 1 Proteins showing differential expression in hVSMCs in response to melittin

1

Q15257

Serine/threonine-protein phosphatase 2A regulatory subunit

C

Apoptosis

560

40

5. 6

1. 603

0. 903

2

Q9Y3V2

RWD domain-containing protein 3

C

Protein binding

400

30

6

1. 589

0. 857

3

P38646

Stress-70 protein

M

Anti-apoptosis

67833

73

5. 9

0. 555

1. 026

4

Q9UJX0

Oxidative stress-induced growth inhibitor 1

C

Ccell growth

112

60

7

3. 456

0. 47

5

O75439

Mitochondrial-processing peptidase subunit beta

M

Proteolysis

138

54

6. 4

0. 331

1. 597

6

O75208

Ubiquinone biosynthesis protein COQ9

M

Ubiquinone biosynthesis

151

35

5. 6

0. 615

1. 579

7

Q99518

Dimethylaniline monooxygenase

ER

Oxidoreductase

161

60

8. 6

0. 434

1. 571

8

P10809

60 kDa heat shock protein

M

Chaperone

730

61

5. 7

0. 553

1. 094

9

Q8N987

N-terminal EF-hand calcium-binding protein 1

C

Calcium ion binding

404

40

4. 8

1. 7

0. 229

10

Q96AB6

Protein N-terminal asparagine amidohydrolase

C

Hydrolase

112

34

5. 8

0. 235

0. 688

11

P08754

Guanine nucleotide-binding protein G(k) subunit alpha

C

Transducer

1704

40

5. 5

1. 631

0. 782

12

P27797

Calreticulin precurso

ER

Signal transducer activity

183

48

4. 3

2. 225

0. 362

13

Q9H361

Polyadenylate-binding protein 3

C

Poly(A) RNA binding

156

70

9. 7

8. 041

0. 25

14

Q6IQ49

Uncharacterized protein C1orf55

Unknown

Unknown

4333

49

5. 8

0. 45

1. 604

15

Q9NPA1

Calcium-activated potassium channel subunit beta-3

CM

Transport

920

31

6. 9

0. 589

2. 289

16

Q9Y603

Transcription factor ETV7

N

Repressor

142

38

8. 3

3. 929

0. 39

17

Q17RB8

LON peptidase N-terminal domain and RING finger protein 1

M

Proteolysis

133

47

5. 6

0. 614

1. 261

18

P35232

Prohibitin

M

DNA replication

1501

29

5. 6

0. 567

1. 581

19

Q9Y262

Eukaryotic translation initiation factor 3 subunit E-interacting protein

C

Initiation factor

1001

66

5. 9

1. 623

1. 01

20

Q9Y512

Sorting and assembly machinery component 50 homolog

M

Protein binding

303

51

6. 4

0. 194

0. 632

21

Q9Y3Q3

Transmembrane emp24 domain-containing protein 3 precursor

G

Transport

1306

24

5. 4

0. 532

1. 024

22

Q15080

Neutrophil cytosol factor 4

C

Immune response

116

39

6. 4

0. 352

0. 985

23

Q12792

Twinfilin-1

C

Regulation of actin phosphorylation

177

42

6. 5

0. 03

2. 558

24

P31321

cAMP-dependent protein kinase type I-beta regulatory subunit

C

Transmembrane transport

219

43

5. 6

0. 504

1. 865

25

Q15080

Neutrophil cytosol factor 4

C

Immune response

104

39

6. 4

0. 881

1. 703

26

Q8N3R9

MAGUK p55 subfamily member 5

C

Tight junction assembly

3244

77

5. 8

4. 311

1. 148

27

P06753

Tropomyosin alpha-3 chain

C

Actin binding

179

32

4. 7

1. 534

0. 473

28

P14550

Alcohol dehydrogenase

C

Oxidoreductase

173

36

6. 3

1. 722

0. 876

29

Q5TZF3

Ankyrin repeat domain-containing protein 45

C

Unknown

2335

31

4. 6

0. 739

2. 151

30

Q16222

UDP-N-acetylhexosamine pyrophosphorylase

C

Transferase

193

58

5. 9

4. 854

0. 304

31

P04083

Annexin A1

C

Anti-apoptosis

271

38

6. 6

0. 6

1. 442

32

P51580

Thiopurine S-methyltransferase

C

Transferase

150

28

5. 8

0. 051

1. 518

33

O14618

Copper chaperone for superoxide dismutase

C

Chaperone

137

29

5. 3

0. 423

1. 27