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Table 1 Proteins showing differential expression in hVSMCs in response to melittin

From: Comparative proteome analysis of Tumor necrosis factor α-stimulated human Vascular Smooth Muscle Cells in response to melittin

  aAC No Protein Localization Function bScore MW PI TNF/Con MEL + TNF/Con
1 Q15257 Serine/threonine-protein phosphatase 2A regulatory subunit C Apoptosis 560 40 5. 6 1. 603 0. 903
2 Q9Y3V2 RWD domain-containing protein 3 C Protein binding 400 30 6 1. 589 0. 857
3 P38646 Stress-70 protein M Anti-apoptosis 67833 73 5. 9 0. 555 1. 026
4 Q9UJX0 Oxidative stress-induced growth inhibitor 1 C Ccell growth 112 60 7 3. 456 0. 47
5 O75439 Mitochondrial-processing peptidase subunit beta M Proteolysis 138 54 6. 4 0. 331 1. 597
6 O75208 Ubiquinone biosynthesis protein COQ9 M Ubiquinone biosynthesis 151 35 5. 6 0. 615 1. 579
7 Q99518 Dimethylaniline monooxygenase ER Oxidoreductase 161 60 8. 6 0. 434 1. 571
8 P10809 60 kDa heat shock protein M Chaperone 730 61 5. 7 0. 553 1. 094
9 Q8N987 N-terminal EF-hand calcium-binding protein 1 C Calcium ion binding 404 40 4. 8 1. 7 0. 229
10 Q96AB6 Protein N-terminal asparagine amidohydrolase C Hydrolase 112 34 5. 8 0. 235 0. 688
11 P08754 Guanine nucleotide-binding protein G(k) subunit alpha C Transducer 1704 40 5. 5 1. 631 0. 782
12 P27797 Calreticulin precurso ER Signal transducer activity 183 48 4. 3 2. 225 0. 362
13 Q9H361 Polyadenylate-binding protein 3 C Poly(A) RNA binding 156 70 9. 7 8. 041 0. 25
14 Q6IQ49 Uncharacterized protein C1orf55 Unknown Unknown 4333 49 5. 8 0. 45 1. 604
15 Q9NPA1 Calcium-activated potassium channel subunit beta-3 CM Transport 920 31 6. 9 0. 589 2. 289
16 Q9Y603 Transcription factor ETV7 N Repressor 142 38 8. 3 3. 929 0. 39
17 Q17RB8 LON peptidase N-terminal domain and RING finger protein 1 M Proteolysis 133 47 5. 6 0. 614 1. 261
18 P35232 Prohibitin M DNA replication 1501 29 5. 6 0. 567 1. 581
19 Q9Y262 Eukaryotic translation initiation factor 3 subunit E-interacting protein C Initiation factor 1001 66 5. 9 1. 623 1. 01
20 Q9Y512 Sorting and assembly machinery component 50 homolog M Protein binding 303 51 6. 4 0. 194 0. 632
21 Q9Y3Q3 Transmembrane emp24 domain-containing protein 3 precursor G Transport 1306 24 5. 4 0. 532 1. 024
22 Q15080 Neutrophil cytosol factor 4 C Immune response 116 39 6. 4 0. 352 0. 985
23 Q12792 Twinfilin-1 C Regulation of actin phosphorylation 177 42 6. 5 0. 03 2. 558
24 P31321 cAMP-dependent protein kinase type I-beta regulatory subunit C Transmembrane transport 219 43 5. 6 0. 504 1. 865
25 Q15080 Neutrophil cytosol factor 4 C Immune response 104 39 6. 4 0. 881 1. 703
26 Q8N3R9 MAGUK p55 subfamily member 5 C Tight junction assembly 3244 77 5. 8 4. 311 1. 148
27 P06753 Tropomyosin alpha-3 chain C Actin binding 179 32 4. 7 1. 534 0. 473
28 P14550 Alcohol dehydrogenase C Oxidoreductase 173 36 6. 3 1. 722 0. 876
29 Q5TZF3 Ankyrin repeat domain-containing protein 45 C Unknown 2335 31 4. 6 0. 739 2. 151
30 Q16222 UDP-N-acetylhexosamine pyrophosphorylase C Transferase 193 58 5. 9 4. 854 0. 304
31 P04083 Annexin A1 C Anti-apoptosis 271 38 6. 6 0. 6 1. 442
32 P51580 Thiopurine S-methyltransferase C Transferase 150 28 5. 8 0. 051 1. 518
33 O14618 Copper chaperone for superoxide dismutase C Chaperone 137 29 5. 3 0. 423 1. 27
  1. a The Swiss-Prot/TrEMBL database accession number. b protein score greater than 100 are significant (p < 0.05). CM: Cell membrane, ER: Endoplasmic reticulum, M: Mitochondrion, N: Nucleus, C: Cytoplasm, G: Golgi apparatus, L: Lysosome, S: Secreted, MC: Microtubule.