Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients

Table 2 Significantly regulated proteins in three out of five high Mankin scored individuals

Gene names	Protein names	UniProt	SILAC protein ratio
			HM. 1	HM. 2	HM. 3	HM. 4	HM. 5
Significance in 3 of 5 pat.
ENO3	Enolase 3	P13929-2	NR	12.53	NR	10.85	11.41
STAB1	Stabilin 1	Q9NY15	0.18	0.05	0.02	0.42	0.05
TF	Serotransferrin	A0PJA6	0.16	0.14	0.06	0.12	0.06
SPRR2C	Small proline-rich protein	Q15515	0.25	0.20	0.09	0.25	NR
DMD	Dystrophin	P11532-1	0.09	0.08	0.05	0.09	0.08
DPYSL3	Collapsin response mediator protein 4 long variant	B3SXQ8	0.14	0.09	0.09	0.11	0.13

Medially abundant protein groups have SILAC ratios >1. Laterally abundant protein groups have SILAC ratios <1. Significant SILAC ratios are in italics. NR= No Ratio.

ISSN: 1477-5956