Table 3 Enriched protein groups in the medial femur condyle of the low Mankin individual and SILAC ratios in all individuals

LM I

LM II

HM. 1

HM. 2

HM. 3

HM. 4

HM. 5

TIMP1*

Tissue inhibitor of metalloproteinases 1

P01033

95.7692

0.0027

1.5998

1.1847

1.3414

0.4638

0.8376

IGFBP6*

Insulin-like growth factor binding protein 6

P24592

68.0973

0.0018

NR

0.1656

NR

0.1418

1.0172

IGFBP7*

Insulin-like growth factor-binding protein 7

Q16270

56.9646

0.0027

1.4450

1.4334

2.8779

1.6507

1.4007

EFEMP1*

EGF-containing fibulin-like ECM protein 1

Q12805

55.6707

0.0018

1.1036

0.2390

2.2981

0.3037

0.2289

TIMP2*

Tissue inhibitor of metalloproteinases 2

P16035

55.6099

0.0016

1.6216

1.3963

NR

0.9244

1.0870

FSTL1*

Follistatin-like protein 1

Q12841

50.4631

0.0036

1.7105

1.1239

3.4944

1.1685

1.0447

CST3*

Cystatin-3

P01034

48.8661

0.0038

1.5492

0.5319

NR

0.9870

1.1611

IGFBP3

Insulin-like growth factor-binding protein 3

P17936

47.2340

0.0019

1.2820

0.3277

NR

0.5362

0.8611

CHI3L1*

Cartilage glycoprotein 39

P36222

45.1381

0.0040

0.7167

0.8409

3.2179

0.4490

0.3307

LUM*

Lumican

P51884

44.3039

0.0025

1.4396

1.1753

1.7528

0.9746

0.6962

SERPINE2*

Serpin E2

B4DIF2

39.5572

0.0062

0.7233

2.3149

NR

2.2748

NR

IGFBP4*

Insulin-like growth factor-binding protein 4

P22692

39.1861

0.0022

0.3036

0.2409

1.4139

0.2510

0.1026

SPARC

Osteonectin

P09486

36.7189

0.0050

1.1554

0.5516

3.3970

1.1862

0.4348

CTSB*

Cathepsin B

P07858

36.2281

0.0045

0.8972

1.7551

NR

0.8085

0.7847

PCOLCE*

Procollagen C-endopeptidase enhancer 1

Q15113

33.0022

0.0021

1.1413

1.6081

NR

0.6564

0.8188

QSOX1*

Quiescin Q6 Sulfhydryl oxidase 1

O00391

30.8917

0.0028

0.3646

0.2358

NR

0.3496

0.1460

SERPINE1*

Serpin E1

P05121

24.9099

0.0107

1.9987

0.3301

1.1686

0.8524

0.8781

CYTL1*

Cytokine-like protein 1

Q9NRR1

23.5861

0.0038

NR

NR

NR

0.3065

0.1061

FBN1

Fibrillin-1

P35555

23.5613

0.0042

1.5900

0.7567

1.2034

0.7985

1.1273

COL12A1*

Collagen alpha-1(XII) chain

Q99715

22.5922

0.0088

0.7853

0.7624

1.2400

0.5582

0.7052

B2M*

Beta-2-microglobulin

P61769

20.8405

0.0136

1.2302

1.8824

2.5573

1.0522

0.9875

COL6A1*

Collagen alpha-1(VI) chain

P12109

17.4001

0.0076

1.1075

1.0954

NR

0.9453

1.0361

S100A8*

S100 calcium-binding protein A8

P05109

10.4904

0.0016

NR

0.2692

0.4050

0.2882

NR

COL1A2

Collagen alpha-2(I) chain

P08123

6.9371

0.0079

0.7605

0.5581

NR

0.3964

0.9798

FN1

Fibronectin 1

Q14328

6.5113

0.0077

NR

NR

NR

0.6257

NR

COL1A1*

Collagen alpha-1(I) chain

P02452

5.9307

0.0219

0.9983

1.0441

0.9875

0.9924

1.0064

TPD52L2

Tumor protein D52-like 2

Q5JWU6

3.2973

0.5148

1.2657

NR

NR

NR

NR

CFB

Complement factor B

Q53F89

3.1730

0.0029

NR

NR

NR

0.6802

NR

CLEC3B*

C-type lectin domain family 3 member B

P05452

2.6487

0.0037

NR

2.4076

NR

1.0038

0.7486

TUBB

Tubulin beta chain

P07437

2.4448

0.5533

1.1187

NR

1.1792

NR

NR

CALU

Calumenin

B3KPG9

2.2541

0.1224

1.1768

1.2613

1.3553

1.6319

1.4068

UGDH

UDP-glucose 6-dehydrogenase

O60701

2.1286

0.4052

1.1356

NR

NR

NR

NR

DSP*

Desmoplakin

P15924

2.0360

0.0050

0.2379

0.2814

0.1133

0.1970

NR

IDH1

Isocitrate dehydrogenase 1 (NADP+), soluble

O75874

1.9970

0.3614

1.0508

NR

NR

NR

NR