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Table 4 The most up-regulated proteins in the LM femur lateral secretome

From: Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients

Gene names

Protein names

UniProt

SILAC protein ratio

SILAC protein ratio

   

LM I

LM II

HM. 1

HM. 2

HM. 3

HM. 4

HM. 5

UBE2N

Ubiquitin-conjugating enzyme E2 N

P61088

0.0124

9.5421

0.9613

0.6917

NR

NR

0.8378

LXN

Latexin

Q9BS40

0.0134

5.9971

NR

0.6758

NR

NR

0.5899

ACTBL2*

Beta-actin-like protein 2

Q562R1

0.0233

4.9112

0.9809

0.5849

0.7814

0.2662

0.5782

TXNDC5

Thioredoxin domain-containing protein 5

Q8NBS9

0.0262

11.4810

0.8763

0.9413

0.8426

0.7740

0.6789

YWHAE

14-3-3 protein epsilon

P62258

0.0352

12.7140

1.1072

0.9430

1.0612

0.9204

0.8249

CA2

Carbonic anhydrase 2

P00918

0.0353

11.8720

0.7900

0.8925

1.3874

0.9696

0.5556

FHL1

Four and a half LIM domains protein 1

Q13642-1

0.0356

18.3770

1.0419

0.5525

0.7408

0.9364

1.1789

PFN1

Profilin I

P07737

0.0381

10.4650

1.0302

0.8745

0.8038

0.9245

1.0736

PGAM1*

Phosphoglycerate mutase 1

P18669

0.0388

10.9160

0.9279

0.7419

0.6064

1.1168

0.9556

TPI

Triosephosphate isomerase

Q53HE2

0.0424

11.0430

1.0331

1.0640

1.1490

1.0830

1.1780

RSU1

Ras suppressor protein 1

Q15404

0.0428

8.9161

1.0096

0.6922

0.6630

NR

0.8345

GSTO1

Glutathione S-transferase omega-1

P78417

0.0430

23.5890

0.9591

0.8911

NR

NR

NR

AKR1B1

Aldehyde reductase

P15121

0.0439

21.0670

0.7693

1.0281

1.0159

NR

0.8704

STMN1

Stathmin

B7Z8N4

0.0452

13.8150

0.9782

0.6731

1.3752

0.6255

0.8742

YWHAB

14-3-3 protein beta/alpha

P31946-2

0.0456

48.1920

1.0435

0.9433

0.8530

0.9862

0.8862

ALDOA

Fructose-bisphosphate aldolase A

P04075

0.0458

11.5280

0.9721

0.6382

0.7641

0.9858

1.0069

YWHAB

14-3-3 protein beta/alpha

P31946-1

0.0465

14.3180

NR

0.9594

NR

NR

NR

MDH1

Malate dehydrogenase, cytoplasmic

P40925

0.0465

14.4410

1.0407

0.9923

1.0104

1.0328

0.8833

FTL

Ferritin light chain

P02792

0.0488

24.5770

0.7289

0.6701

NR

NR

0.5221

YWHAZ*

14-3-3 protein zeta/delta

P63104

0.0498

18.0160

1.0942

0.9132

1.0023

1.0695

0.9371

EIF5A

Eukaryotic translation initiation factor 5A-1

P63241-2

0.0550

16.9460

1.0730

0.8086

NR

NR

0.9224

ARHGDIA

Rho GDP-dissociation inhibitor 1

P52565

0.0556

14.7570

0.8920

0.6763

NR

0.9223

0.8761

LDHB

L-lactate dehydrogenase B chain

P07195

0.0582

13.1470

0.9911

0.7294

0.7403

0.8234

0.8016

AKAP12

A-kinase anchor protein 12

Q02952-1

0.1125

22.0240

NR

NR

NR

NR

NR

SCRN1

Secernin-1

Q12765

0.1244

11.0260

NR

NR

NR

NR

NR

ANXA1*

Annexin A1

P04083

0.1407

99.8340

1.8046

0.8261

1.1868

NR

1.2625

EPB41L2

Band 4,1-like protein 2

O43491

0.1462

11.4150

NR

NR

NR

NR

NR

FABP3

Fatty acid-binding protein 3

P05413

0.1541

23.3740

NR

NR

NR

NR

NR

ANXA5*

Annexin A5

P08758

0.1546

6.0555

1.4520

NR

1.1515

NR

NR

S100A11*

Protein S100-A11

P31949

0.1830

7.7868

1.1976

0.8693

0.8680

0.9675

1.0495

CDV3

Protein CDV3 homolog

Q9UKY7-1

0.2226

16.6240

NR

NR

NR

NR

NR

  1. Total list is available in the Additional file 7: Table S7.
  2. LM I = Low Mankin scored individual experiment one. LM II = Low Mankin scored individual experiment two. HM.1-5 = High Mankin scored individual 1–5. NR = No Ratio.
  3. * = Proteins identified both in the explant and monolayer secretomes.