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Table 6 Prediction performance on the HLA-DR T-cell epitope dataset.

From: An effective and effecient peptide binding prediction approach for a broad set of HLA-DR molecules based on ordered weighted averaging of binding pocket profiles

Allele

# epitopes

OWA-PSSM

TEPITOPE

TEPITOPEpan

MultiRTA

NetMHCIIpan-2.0

DRB1*0101

125

0.807

0.795

0.808

0.786

0.810

DRB1*0102

4

0.790

0.761

0.792

0.822

0.879

DRB1*0103

5

0.837

 

0.719

0.528

0.667

DRB1*0301

173

0.632

0.637

0.640

0.655

0.683

DRB1*0401

342

0.747

0.741

0.743

0.707

0.775

DRB1*0402

33

0.575

0.574

0.571

0.521

0.570

DRB1*0403

14

0.904

 

0.905

0.848

0.896

DRB1*0404

46

0.732

0.732

0.738

0.715

0.744

DRB1*0405

21

0.745

0.746

0.722

0.579

0.626

DRB1*0406

6

0.766

 

0.753

0.869

0.741

DRB1*0407

4

0.808

 

0.824

0.749

0.668

DRB1*0408

2

0.930

0.930

0.930

0.999

0.986

DRB1*0701

56

0.737

0.720

0.736

0.736

0.742

DRB1*0703

1

0.905

0.911

0.915

0.707

0.896

DRB1*0801

4

0.586

0.554

0.640

0.716

0.663

DRB1*0802

2

0.848

0.866

0.850

0.685

0.754

DRB1*0803

2

0.548

 

0.516

0.707

0.852

DRB1*0901

13

0.729

 

0.697

0.636

0.738

DRB1*1001

4

0.870

 

0.835

0.789

0.875

DRB1*1101

88

0.752

0.745

0.751

0.703

0.815

DRB1*1102

1

0.843

0.828

0.822

0.503

0.493

DRB1*1103

3

0.333

 

0.328

0.480

0.510

DRB1*1104

6

0.793

0.810

0.805

0.666

0.807

DRB1*1201

3

0.876

 

0.887

0.862

0.970

DRB1*1301

15

0.767

0.783

0.756

0.642

0.632

DRB1*1302

10

0.832

0.809

0.813

0.781

0.860

DRB1*1303

3

0.482

 

0.562

0.515

0.604

DRB1*1401

16

0.718

 

0.781

0.697

0.789

DRB1*1404

1

0.930

 

0.949

0.938

0.956

DRB1*1405

2

0.861

 

0.807

0.848

0.839

DRB1*1501

193

0.688

0.681

0.690

0.665

0.722

DRB1*1502

20

0.611

0.605

0.608

0.570

0.681

DRB1*1503

2

0.802

 

0.829

0.531

0.874

DRB1*1601

5

0.684

 

0.699

0.721

0.724

DRB1*1602

3

0.885

 

0.912

0.886

0.984

DRB3*0101

12

0.875

 

0.833

0.883

0.895

DRB3*0202

10

0.588

 

0.613

0.466

0.539

DRB3*0301

1

0.988

 

0.885

0.906

0.966

DRB4*0101

17

0.663

 

0.560

0.583

0.789

DRB4*0103

1

0.990

 

0.990

0.992

0.991

DRB5*0101

55

0.746

0.738

0.747

0.752

0.802

DRB5*0102

1

0.909

 

0.870

0.752

0.987

Average

 

0.764

0.748

0.758

0.717

0.781

Average I

 

0.753

0.748

0.754

0.696

0.747

Average II

 

0.775

 

0.761

0.736

0.812

  1. "Average" is the average over 42 alleles. "Average I" is the average over 20 alleles predictable by TEPITOPE.
  2. "Average II" is the average over 22 alleles not predictable by TEPITOPE. The PSSMs of TEPITOPE, TEPITOPEpan and the results of MultiRTA were obtained from their respective web servers. The prediction of NetMHCIIpan-2.0 were obtained directly from its publication.
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