Figure 2

Heatmap representing the degree of associations between disease/therapeutic classes and membrane proteins. The disease associations were measured with first level classes of the ICD-10-CM, which were used to integrate the disease and drug information (a). For the therapeutic associations, the first level codes of ATC, which were used for the classification of integrated drugs depend on their therapeutic characteristics, were used (b). The degree of association was measured by hypergeometric test with FDR multiple testing correction. Only significantly enriched results with p-value below 0.01 are colored in the diagram. MP means all membrane proteins in this database.