Figure 3

The key signaling pathways involved in the early recurrence/metastasis (R/M _≤6months ) and late recurrence/metastasis (R/M _6-12months ) of H-HCC. (A) The alternations of the ERK1/2 signaling pathway in the R/M_≤6months group, including 6 up-regulated proteins (red labeling) and 7 down-regulated (green labeling) proteins. (B) The alternations of the TNF signaling pathway in the R/M_≤6months group, including 4 up-regulated proteins (red labeling) and 9 down-regulated proteins (green labeling). (C) The alternations of the TNF signaling pathway in the R/M_6-12months group, including 7 up-regulated proteins (red labeling) and 5 down-regulated proteins (green labeling). (D) the alternations of the NFκB signaling pathway in the R/M_6-12months group, including 9 up-regulated proteins (red labeling) and 2 down-regulated (green labeling) proteins.