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Table 1 List of proteins with different abundance in cancer cell lines

From: Comparative proteomics analysis of oral cancer cell lines: identification of cancer associated proteins

Protein name

Ascension number (Swissprot)/matched 2D coordinates

MW/pI

Peptides (% cov)

Relative change vs normal

Zoomed in gel image showing representative spots

Abbreviation

(World-2DPAGE portal)

  

Theory

Experimental

  

Normal

Cancer

Structural

20

Stathmin (Phosphoprotein p19)

P16949 /SPOT 2D-001YH8

17.3/5.76

>15.0/5.7

4 (18%)

+1.6

STMN1

1

Tropomyosin alpha-3 chain (Tropomyosin-3)

P06753 /

32.8/4.68

>30.0/4.6

6 (13%)

-1.5

SPOT 2D-001EM1

SPOT 2D-001YBH

TPM3

SPOT 2D-001JNO

4

Myosin regulatory light chain-2

P19105 /

19.8/4.67

>15.0/4.60

5 (17%)

-1.9

SPOT 2D-001JUH

ML12A

SPOT 2D-001JUS

Enzymes

6

Lactoylglutathione lyase (Glyoxalase I). (EC 4.4.1.5)

Q04760 /

20.8/5.12

>20.0/5.00

10 (22%)

+7.7

LGUL

n/a

24

Triosephosphate isomerase (EC 5.3.1.1)

P60174 /

26.7/6.45

>25.0/6.5

5 (28%)

+2.5

TPIS

SPOT 2D-0003MP

18

Nucleoside diphosphate kinase A (EC 2.7.4.6)

P15531 /

17.1/5.83

>15.0/5.8

8 (31%)

+1.5

NDKA

n/a

21

Ubiquitin-conjugating enzyme E2 N (EC 6.3.2.19)

P61088 /

17.1/6.13

>15.0/5.9

6 (23%)

+2.6

UBE2N

n/a

16

Gamma-glutamylcyclotransferase (EC 2.3.2.4)

O75223 /

21.0/5.07

>20.0/5.0

3 (27%)

+2.5

GGCT

n/a

14

Peroxiredoxin-4 (EC 1.11.1.15)

Q13162 /

30.5/5.86

>30.0/5.8

6 (16%)

+2.2

PRDX4

n/a

19

Superoxide dismutase [Cu-Zn] (EC 1.15.1.1)

P00441 /

15.9/5.70

>15.0/5.70

5 (24%)

+1.4

SPOT 2D-001F1V

SODC

SPOT 2D-000ZXR

17

Glutathione S-transferase P (GST class-pi). (EC 2.5.1.18)

P09211 /

23.3/5.43

>25/5.6

8 (22%)

+1.4

SPOT 2D-001EUM

SPOT 2D-0003Q9

GSTP1

SPOT 2D-00085X

11

Proteasome subunit beta type 4 precursor. (EC 3.4.25.1)

P28070 /

29.2/5.72

29.0/5.7

6 (15%)

+1.6

SPOT 2D-000851

PSB4

SPOT 2D-000D4M

Regulatory proteins

3

14-3-3 protein beta/alpha

P31946 /

28.0/4.70

>25.0/4.50

6 (4%)

+1.8

1433B

n/a

12

Prohibitin

P35232 /

29.8/5.57

>25.0/5.60

5 (12%)

+1.6

PHB

SPOT 2D-001EOL

13

Proteasome activator complex subunit 1

Q06323 /

28.7/5.78

>25.0/5.70

2 (4%)

-1.7

PSME1

SPOT 2D-001YC7

16

Proteasome activator complex subunit 2

Q9UL46 /

27.3/5.44

>30.0/5.4

4 (11%)

-2.3

PSME2

n/a

2

14-3-3 protein sigma (Stratifin)

P31947 /

27.8/4.68

>25.0/4.50

9 (24%)

-2.0

1433S

SPOT 2D-001EP6

22

Stress-induced-phosphoprotein 1

P31948 /

62.6/6.4

>55.0/6.50

11 (12%)

+2.1

STIP1

n/a

10

Interleukin-1 receptor antagonist protein precursor

P18510 /

20.0/5.83

>20.0/5.3

2 (8%)

+1.3

IL1RA

n/a

5

Rho GDP-dissociation inhibitor 1

P52565 /

23.2/5.02

30.0/5.0

4 (14%)

+2.6

GDIR

n/a

9

Ran-specific GTPase-activating protein

P43487 /

23.3/5.19

30/5.2

5 (18%)

+1.8

RANG

n/a

Chaperones

15

Heat-shock protein beta-1

P04792 /

22.8/6.00

>20.0/5.8

11 (32%)

+3.1

SPOT 2D-001JQI

HSPB1

SPOT 2D-001JQP

23

T-complex protein 1 subunit zeta-2

Q92526 /

57.7/6.63

>55.0/6.8

2 (2%)

-1.6

TCPW

n/a

Others

8

Chloride intracellular channel protein 1 (membrane associated)

O00299 /

26.9/5.09

>30.0/5.1

14 (46%)

-1.7

 

CLIC1

SPOT 2D-001YBL

      
  1. The proteins were grouped into five functional categories – structural proteins, enzymes, regulatory proteins, chaperones and others. The accession number (swiss-prot) and matched 2D coordinates, molecular weight and pI (theoretical and experimental), number of matched peptides, percentage coverage, relative change vs normal and zoomed in gel image showing representative spots are shown.
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