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Figure 5 | Proteome Science

Figure 5

From: Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality

Figure 5

Phospho markers are predictive of prostate cancer outcome. A) Kaplan-Meier curves for survival as a function of single biomarker protein expression in the study cohort (pS6, pPRAS40, FOXO3, p90RSK). B) Univariate survival analysis. The population with the top 1/3 of risk score values was separated from the population with the bottom 2/3 of risk scores. P values (P) and HR are annotated. C) Multivariate Cox regression and logistic regression analyses of survival prediction for our study cohort. The marker combination was used to develop models based on training and testing on the whole cohort. 3 + pS6 + pPRAS40: SMAD4, CCND1, SPP1, pS6, pPRAS40. Logit: Logistic Regression. D) Kaplan-Meier curve for survival as a function of risk scores generated by a Cox model trained on the whole cohort using the 3 + pS6 + pPRAS40 markers. The lowest 2/3 of risk scores was used as threshold for population separation. P value (P) is annotated.

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