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Table 3 Dysregulated proteins in the plasma of MCI subtypes and AD, identified in three iTRAQ biological replicate experiments

From: Plasma protein profiling of Mild Cognitive Impairment and Alzheimer’s disease using iTRAQ quantitative proteomics

Accession No.

Name (Acronym)

Replicate

aMCI: Normal

PVal

nMCI: Normala,b

PVal

AD: Normal

PVal

IPI00855916.1

Transthyretin (TTR)

1

2.15

0 ***

1.15

0.05

1.57

0 ***

2

0.94

0.28

0.93

0.1

1.06

0.28

3

0.91

0.13

1.13

0 ***

1.19

0 ***

IPI00745089.2

alpha 1B-glycoprotein precursor (A1BG)

2

1.09

0.03

1.08

0.01

1.09

0.01

3

1

0.99

1.06

0.02

1.17

0 ***

IPI00477090.6

Ig mu chain C region (IGHM)

1

1.05

0.6

0.97

0.63

1.41

0 ***

2

1.48

0 ***

1.21

0.03

1.57

0 ***

3

1.41

0 ***

1

0.99

1.47

0 ***

IPI00022229.1

Apolipoprotein B-100 (APOB)

1

1.03

0.23

1.31 b

0 ***

1.01

0.73

2

0.99

0.63

1.19 b

0 ***

1.01

0.56

3

1.03

0.17

1.03 b

0.05

1.02

0.18

IPI00032291.2

Complement C5 (C5)

1

1.04

0.5

1.24 b

0 ***

0.99

0.82

2

1

1

1.14 b

0 ***

0.99

0.8

IPI00292530.1

Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

1

1.09

0.17

1.3 b

0.01

1.05

0.25

3

1.24

0.01

1.13 b

0.05

1.05

0.27

IPI00026314.1

Isoform 1 of Gelsolin (GSN)

1

0.99

0.86

1.13 b

0.03

1.04

0.41

2

1.07

0.11

1.14 b

0 ***

1.04

0.24

3

1.15

0 ***

1.09 b

0.02

0.95

0.31

IPI00019591.2

Complement factor B (CFB)

1

0.96

0.14

0.95

0.12

0.95

0.05

2

0.93

0.05

0.91

0 ***

0.94

0.1

3

0.96

0.29

0.95

0.03

0.9

0 ***

IPI00019943.1

Afamin (AFM)

1

0.94

0.32

0.69 b

0 ***

0.95

0.25

2

0.97

0.5

0.83 b

0 ***

0.99

0.8

3

0.69

0 ***

0.87 b

0 ***

1.01

0.79

IPI00021727.1

C4b-binding protein alpha chain (C4BPA)

1

0.93

0.02

1.04

0.22

0.96

0.18

2

0.82

0.01

0.98

0.77

0.97

0.56

3

0.85

0 ***

0.8

0.01

0.82

0 ***

IPI00479116.1

Carboxypeptidase N subunit 2 (CPN2)

1

0.79

0 ***

0.86

0.05

0.83

0.01

2

0.57

0 ***

1.01

0.88

0.74

0 ***

IPI00022371.1

Histidine-rich glycoprotein (HRG)

1

0.99

0.85

0.66 b

0 ***

1.01

0.75

2

1.1

0.07

0.86 b

0.02

1.07

0.07

3

0.87

0.01

0.95

0.15

0.96

0.2

IPI00006662.1

Apolipoprotein D (APOD)

1

0.99

0.92

1.03

0.67

0.83

0.01

3

0.71

0 ***

1.05

0.18

1.06

0.19

IPI00478003.1

Alpha-2-macroglobulin (A2M)

1

0.99

0.42

0.98

0.21

0.92

0 ***

2

1.06

0 ***

0.98

0.11

1.04

0.02

3

1.13

0 ***

0.99

0.44

0.9

0 ***

IPI00021841.1

Apolipoprotein A-I (APOA1)

1

1.38

0 ***

1.05

0.04

1.13

0 ***

2

0.51

0 ***

0.81

0

0.63

0 ***

3

0.66

0 ***

1.03

0.07

1.45

0 ***

IPI00021854.1

Apolipoprotein A-II (APOA2)

1

1.31

0 ***

0.81

0.01

0.85

0 ***

2

0.5

0 ***

0.91

0.05

0.81

0 ***

3

0.53

0 ***

1.06

0.13

0.98

0.68

IPI00304273.2

Apolipoprotein A-IV (APOA4)

1

1.21

0 ***

0.99

0.8

0.97

0.39

2

0.72

0 ***

0.96

0.28

0.83

0 ***

3

0.67

0 ***

0.99

0.85

1.11

0 ***

IPI00021856.3

Apolipoprotein C-II (APOC2)

1

1.49

0.05

1.07

0.68

1.01

0.96

2

0.55

0.01

0.76

0.02

0.61

0.01

3

0.42

0.02

0.7

0.16

0.97

0.92

IPI00298828.3

Beta-2-glycoprotein 1 (APOH)

1

1.01

0.91

0.95

0.23

0.89

0.05

2

1.15

0 ***

0.97

0.43

1.18

0 ***

3

0.8

0 ***

0.97

0.5

0.87

0.01

IPI00783987.2

Complement C3 (C3)

1

0.97

0.07

0.94

0 ***

0.93

0 ***

2

1.01

0.64

0.95

0 ***

0.98

0.24

3

1.14

0 ***

1.01

0.24

0.92

0 ***

IPI00400826.1

Clusterin isoform 1 (CLU)

1

1.1

0.16

1

0.99

1.05

0.36

2

0.92

0.13

0.93

0.07

1.01

0.91

3

0.81

0.02

0.92

0.04

1.14

0.02

IPI00021885.1

Isoform 1 of Fibrinogen alpha chain (FGA)

1

0.94

0 ***

0.93

0 ***

1

0.88

2

1.01

0.76

0.89

0 ***

1.07

0 ***

3

1.15

0 ***

0.95

0.01

1.01

0.76

IPI00298497.3

Fibrinogen beta chain (FGB)

1

0.97

0.15

0.98

0.31

1.01

0.71

2

1.01

0.79

0.92

0 ***

1.05

0.01

3

1.16

0 ***

0.96

0.05

0.96

0.04

IPI00877792.1

Fibrinogen gamma chain (FGG)

1

1.1

0 ***

0.99

0.65

1.09

0 ***

2

0.85

0 ***

0.88

0 ***

0.91

0 ***

3

1.01

0.78

0.91

0 ***

0.92

0 ***

IPI00742696.2

vitamin D-binding protein precursor (GC)

1

1.01

0.83

1

0.88

1.04

0.19

2

0.27

0 ***

0.44

0 ***

0.27

0 ***

3

0.68

0 ***

0.98

0.44

1.07

0.04

IPI00641737.1

Haptoglobin-related protein (HPR)

1

0.87

0 ***

1.08

0.03

0.95

0.23

2

1.1

0 ***

1.06

0.03

1.06

0.05

3

1.07

0.11

0.96

0.27

1.01

0.77

IPI00896413.1

Inter-alpha-trypsin inhibito heavy chain H4 (ITIH4)

1

1.12

0.04

0.77

0.08

0.9

0.21

2

0.94

0.14

0.97

0.25

0.94

0.05

3

0.96

0.24

0.95

0.08

0.93

0.02

IPI00884926.1

Orosomucoid 1 precursor (ORM1)

2

0.85

0 ***

1.03

0.37

0.92

0.1

3

0.59

0 ***

1

0.98

1.07

0.05

IPI00550991.3

Alpha-1-antichymotrypsin (SERPINA3)

1

1.21

0 ***

1.05

0.15

1.17

0 ***

2

0.83

0 ***

0.93

0.05

0.87

0 ***

3

0.99

0.91

1

0.98

1.11

0 ***

IPI00879231.1

Alpha-2-antiplasmin (SERPINF2)

2

0.89

0.25

1.25

0 ***

1

0.99

3

0.86

0.05

1.21

0.01

1.05

0.53

  1. aThis column represents nonamnestic MCI, with either single or multiple domains affected. The data are single and multiple domain unless otherwise indicated. bNonamnestic multiple domain MCI (nmdMCI) data. Boldface data, P<0.05. ***P < 0.001. aMCI, amnestic single and multiple domain MCI. nMCI, nonamnestic single and multiple domain MCI. The IPI human database was used during ProteinPilot processing.
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