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Table 3 Dysregulated proteins in the plasma of MCI subtypes and AD, identified in three iTRAQ biological replicate experiments

From: Plasma protein profiling of Mild Cognitive Impairment and Alzheimer’s disease using iTRAQ quantitative proteomics

Accession No. Name (Acronym) Replicate aMCI: Normal PVal nMCI: Normala,b PVal AD: Normal PVal
IPI00855916.1 Transthyretin (TTR) 1 2.15 0 *** 1.15 0.05 1.57 0 ***
2 0.94 0.28 0.93 0.1 1.06 0.28
3 0.91 0.13 1.13 0 *** 1.19 0 ***
IPI00745089.2 alpha 1B-glycoprotein precursor (A1BG) 2 1.09 0.03 1.08 0.01 1.09 0.01
3 1 0.99 1.06 0.02 1.17 0 ***
IPI00477090.6 Ig mu chain C region (IGHM) 1 1.05 0.6 0.97 0.63 1.41 0 ***
2 1.48 0 *** 1.21 0.03 1.57 0 ***
3 1.41 0 *** 1 0.99 1.47 0 ***
IPI00022229.1 Apolipoprotein B-100 (APOB) 1 1.03 0.23 1.31 b 0 *** 1.01 0.73
2 0.99 0.63 1.19 b 0 *** 1.01 0.56
3 1.03 0.17 1.03 b 0.05 1.02 0.18
IPI00032291.2 Complement C5 (C5) 1 1.04 0.5 1.24 b 0 *** 0.99 0.82
2 1 1 1.14 b 0 *** 0.99 0.8
IPI00292530.1 Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) 1 1.09 0.17 1.3 b 0.01 1.05 0.25
3 1.24 0.01 1.13 b 0.05 1.05 0.27
IPI00026314.1 Isoform 1 of Gelsolin (GSN) 1 0.99 0.86 1.13 b 0.03 1.04 0.41
2 1.07 0.11 1.14 b 0 *** 1.04 0.24
3 1.15 0 *** 1.09 b 0.02 0.95 0.31
IPI00019591.2 Complement factor B (CFB) 1 0.96 0.14 0.95 0.12 0.95 0.05
2 0.93 0.05 0.91 0 *** 0.94 0.1
3 0.96 0.29 0.95 0.03 0.9 0 ***
IPI00019943.1 Afamin (AFM) 1 0.94 0.32 0.69 b 0 *** 0.95 0.25
2 0.97 0.5 0.83 b 0 *** 0.99 0.8
3 0.69 0 *** 0.87 b 0 *** 1.01 0.79
IPI00021727.1 C4b-binding protein alpha chain (C4BPA) 1 0.93 0.02 1.04 0.22 0.96 0.18
2 0.82 0.01 0.98 0.77 0.97 0.56
3 0.85 0 *** 0.8 0.01 0.82 0 ***
IPI00479116.1 Carboxypeptidase N subunit 2 (CPN2) 1 0.79 0 *** 0.86 0.05 0.83 0.01
2 0.57 0 *** 1.01 0.88 0.74 0 ***
IPI00022371.1 Histidine-rich glycoprotein (HRG) 1 0.99 0.85 0.66 b 0 *** 1.01 0.75
2 1.1 0.07 0.86 b 0.02 1.07 0.07
3 0.87 0.01 0.95 0.15 0.96 0.2
IPI00006662.1 Apolipoprotein D (APOD) 1 0.99 0.92 1.03 0.67 0.83 0.01
3 0.71 0 *** 1.05 0.18 1.06 0.19
IPI00478003.1 Alpha-2-macroglobulin (A2M) 1 0.99 0.42 0.98 0.21 0.92 0 ***
2 1.06 0 *** 0.98 0.11 1.04 0.02
3 1.13 0 *** 0.99 0.44 0.9 0 ***
IPI00021841.1 Apolipoprotein A-I (APOA1) 1 1.38 0 *** 1.05 0.04 1.13 0 ***
2 0.51 0 *** 0.81 0 0.63 0 ***
3 0.66 0 *** 1.03 0.07 1.45 0 ***
IPI00021854.1 Apolipoprotein A-II (APOA2) 1 1.31 0 *** 0.81 0.01 0.85 0 ***
2 0.5 0 *** 0.91 0.05 0.81 0 ***
3 0.53 0 *** 1.06 0.13 0.98 0.68
IPI00304273.2 Apolipoprotein A-IV (APOA4) 1 1.21 0 *** 0.99 0.8 0.97 0.39
2 0.72 0 *** 0.96 0.28 0.83 0 ***
3 0.67 0 *** 0.99 0.85 1.11 0 ***
IPI00021856.3 Apolipoprotein C-II (APOC2) 1 1.49 0.05 1.07 0.68 1.01 0.96
2 0.55 0.01 0.76 0.02 0.61 0.01
3 0.42 0.02 0.7 0.16 0.97 0.92
IPI00298828.3 Beta-2-glycoprotein 1 (APOH) 1 1.01 0.91 0.95 0.23 0.89 0.05
2 1.15 0 *** 0.97 0.43 1.18 0 ***
3 0.8 0 *** 0.97 0.5 0.87 0.01
IPI00783987.2 Complement C3 (C3) 1 0.97 0.07 0.94 0 *** 0.93 0 ***
2 1.01 0.64 0.95 0 *** 0.98 0.24
3 1.14 0 *** 1.01 0.24 0.92 0 ***
IPI00400826.1 Clusterin isoform 1 (CLU) 1 1.1 0.16 1 0.99 1.05 0.36
2 0.92 0.13 0.93 0.07 1.01 0.91
3 0.81 0.02 0.92 0.04 1.14 0.02
IPI00021885.1 Isoform 1 of Fibrinogen alpha chain (FGA) 1 0.94 0 *** 0.93 0 *** 1 0.88
2 1.01 0.76 0.89 0 *** 1.07 0 ***
3 1.15 0 *** 0.95 0.01 1.01 0.76
IPI00298497.3 Fibrinogen beta chain (FGB) 1 0.97 0.15 0.98 0.31 1.01 0.71
2 1.01 0.79 0.92 0 *** 1.05 0.01
3 1.16 0 *** 0.96 0.05 0.96 0.04
IPI00877792.1 Fibrinogen gamma chain (FGG) 1 1.1 0 *** 0.99 0.65 1.09 0 ***
2 0.85 0 *** 0.88 0 *** 0.91 0 ***
3 1.01 0.78 0.91 0 *** 0.92 0 ***
IPI00742696.2 vitamin D-binding protein precursor (GC) 1 1.01 0.83 1 0.88 1.04 0.19
2 0.27 0 *** 0.44 0 *** 0.27 0 ***
3 0.68 0 *** 0.98 0.44 1.07 0.04
IPI00641737.1 Haptoglobin-related protein (HPR) 1 0.87 0 *** 1.08 0.03 0.95 0.23
2 1.1 0 *** 1.06 0.03 1.06 0.05
3 1.07 0.11 0.96 0.27 1.01 0.77
IPI00896413.1 Inter-alpha-trypsin inhibito heavy chain H4 (ITIH4) 1 1.12 0.04 0.77 0.08 0.9 0.21
2 0.94 0.14 0.97 0.25 0.94 0.05
3 0.96 0.24 0.95 0.08 0.93 0.02
IPI00884926.1 Orosomucoid 1 precursor (ORM1) 2 0.85 0 *** 1.03 0.37 0.92 0.1
3 0.59 0 *** 1 0.98 1.07 0.05
IPI00550991.3 Alpha-1-antichymotrypsin (SERPINA3) 1 1.21 0 *** 1.05 0.15 1.17 0 ***
2 0.83 0 *** 0.93 0.05 0.87 0 ***
3 0.99 0.91 1 0.98 1.11 0 ***
IPI00879231.1 Alpha-2-antiplasmin (SERPINF2) 2 0.89 0.25 1.25 0 *** 1 0.99
3 0.86 0.05 1.21 0.01 1.05 0.53
  1. aThis column represents nonamnestic MCI, with either single or multiple domains affected. The data are single and multiple domain unless otherwise indicated. bNonamnestic multiple domain MCI (nmdMCI) data. Boldface data, P<0.05. ***P < 0.001. aMCI, amnestic single and multiple domain MCI. nMCI, nonamnestic single and multiple domain MCI. The IPI human database was used during ProteinPilot processing.