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Table 2 Quantified hypothetical proteins in hippocampus of SOD1-TG and wild types.

From: Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1

   

Transgenic SOD1 mice

 

Protein name

 

Wild-type (n = 7)

Hemizygous (n = 8)

Homozygous (n = 11)

 

2610008O03Rik protein (Q9D0K2)

1.991 ± 0.318

1.440 ± 0.242

1.343 ± 0.206*

S

4632432E04Rik protein (Q9D358)

0.448 ± 0.087

0.433 ± 0.084*

0.287 ± 0.049**

S

Hypothetical protein (Q99KP6)

0.351 ± 0.051

0.430 ± 0.055*

0.445 ± 0.084*

S

Mouse SOD1 (P08228)

3.584 ± 0.771

2.405 ± 0.289*

2.236 ± 0.419***

S

Human SOD1†(P00441)

spot 1

ND

2.296 ± 0.684

3.387 ± 1.289*

S

 

spot 2

ND

9.948 ± 1.741

11.284 ± 1.314*

S

 

sum

ND

12.244 ± 2.259

14.671 ± 1.804*

S

Mu-crystallin homolog (O54983)

0.708 ± 0.233

0.597 ± 0.197

0.589 ± 0.148

NS

Similar to mitochondrial aconitase (Q99KI0)

spot 1

1.169 ± 0.308

1.211 ± 0.283

1.186 ± 0.412

NS

 

spot 2

1.456 ± 0.260

1.823 ± 0.344

1.515 ± 0.540

NS

 

spot 3

1.341 ± 0.532

1.959 ± 0.631

1.565 ± 0.476

NS

 

sum

3.966 ± 0.994

4.992 ± 0.915

4.266 ± 1.305

NS

2410006N07Rik protein (Q9CWS0)

1.031 ± 0.158

1.135 ± 0.244

1.132 ± 0.269

NS

3110052N05Rik protein (Q9CXN1)

0.373 ± 0.078

0.392 ± 0.126

0.380 ± 0.130

NS

2610103L06Rik protein (Q9D051)

2.311 ± 0.865

2.927 ± 0.378

2.986 ± 0.719

NS

4930529O08Rik protein (Q9D2G2)

0.301 ± 0.092

0.315 ± 0.112

0.404 ± 0.103

NS

Swiprosin 1 (Q9D8Y0)

0.636 ± 0.216

0.669 ± 0.263

0.655 ± 0.260

NS

Similar to DJ-1 protein (Q99LX0)

1.167 ± 0.245

1.310 ± 0.119

1.249 ± 0.260

NS

Germline-encoded VH3 immunoglobulin binding- locus (AAA59434)

0.458 ± 0.190

0.515 ± 0.146

0.432 ± 0.263

NS

ORF 1 (Q61786)

0.263 ± 0.044

0.323 ± 0.060

0.266 ± 0.062

NS

Hypothetical protein FLJ10849 (Q9NVA2)

0.488 ± 0.070

0.541 ± 0.192

0.506 ± 0.101

NS

  1. Spots were quantified using the 2D Image Master software following selection of an area of interest. Between-group differences were analyzed with non-parametric †Mann-Whitney U test or Kruskall-Wallis test. ND, not detected; NS, not significant; S, significant: * P > 0.05; **P > 0.01; ***P > 0.001