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Table 1 CSF proteins increased or decreased, at least two fold in FTD vs. control

From: Validation of a prefractionation method followed by two-dimensional electrophoresis – Applied to cerebrospinal fluid proteins from frontotemporal dementia patients

Spot no.

Protein identity

NCBI Acc. no.

Theor. Mw (kDa)

Theor.pI

No. peptides matched

Seq. cov. (%)

Levels in FTD vs. control

FTD spot norm. density (mean ± SD)

Control spot norm. density (mean ± SD)

1

Zn-α-2-glycoprotein

141596

31.6

5.70

4

22

42256 ± 7227

4189 ± 979

2

proapolipo- protein A1

178775

28.9

5.45

14

43

11572 ± 10432

4575 ± 2309

3

retinol- binding protein

20141667

20.9

5.27

4

35

3680 ± 1675

8131 ± 4857

4

serum albumin

113576

52.0

5.69

11

22

1819 ± 1657

7272 ± 1812

5

serum albumin

113576

52.0

5.69

11

22

2415 ± 964

7839 ± 1906

6

serum albumin

113576

66.0

5.69

12

20

1003 ± 309

3098 ± 1428

7

serum albumin

113576

66.0

5.69

9

15

1528 ± 587

4896 ± 2551

8

alloalbumin

178345

69.2

5.99

12

19

1361 ± 530

7454 ± 1748

9

alloalbumin

178345

69.2

5.99

12

19

2463 ± 806

8395 ± 1475

10

retinol-binding protein

20141667

20.9

5.27

4

35

1744 ± 551

5871 ± 2040

11

transthyretin

339685

13.8

5.3

8

81

45198 ± 26202

9149 ± 2685

12

transthyretin

339685

13.8

5.3

8

81

303002 ± 72750

147732 ± 30928

13

β-2-microglobulin

4757826

12.9

5.77

5

46

41938 ± 43510

12287 ± 3161

  1. The proteins were identified by MALDI-MS. The spot numbers refer to those given in figure 4.