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Table 1 CSF proteins increased or decreased, at least two fold in FTD vs. control

From: Validation of a prefractionation method followed by two-dimensional electrophoresis – Applied to cerebrospinal fluid proteins from frontotemporal dementia patients

Spot no. Protein identity NCBI Acc. no. Theor. Mw (kDa) Theor.pI No. peptides matched Seq. cov. (%) Levels in FTD vs. control FTD spot norm. density (mean ± SD) Control spot norm. density (mean ± SD)
1 Zn-α-2-glycoprotein 141596 31.6 5.70 4 22 42256 ± 7227 4189 ± 979
2 proapolipo- protein A1 178775 28.9 5.45 14 43 11572 ± 10432 4575 ± 2309
3 retinol- binding protein 20141667 20.9 5.27 4 35 3680 ± 1675 8131 ± 4857
4 serum albumin 113576 52.0 5.69 11 22 1819 ± 1657 7272 ± 1812
5 serum albumin 113576 52.0 5.69 11 22 2415 ± 964 7839 ± 1906
6 serum albumin 113576 66.0 5.69 12 20 1003 ± 309 3098 ± 1428
7 serum albumin 113576 66.0 5.69 9 15 1528 ± 587 4896 ± 2551
8 alloalbumin 178345 69.2 5.99 12 19 1361 ± 530 7454 ± 1748
9 alloalbumin 178345 69.2 5.99 12 19 2463 ± 806 8395 ± 1475
10 retinol-binding protein 20141667 20.9 5.27 4 35 1744 ± 551 5871 ± 2040
11 transthyretin 339685 13.8 5.3 8 81 45198 ± 26202 9149 ± 2685
12 transthyretin 339685 13.8 5.3 8 81 303002 ± 72750 147732 ± 30928
13 β-2-microglobulin 4757826 12.9 5.77 5 46 41938 ± 43510 12287 ± 3161
  1. The proteins were identified by MALDI-MS. The spot numbers refer to those given in figure 4.