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Table 1 Protein groups identified in B. atrox venom proteome. Groups from A to Δ comprise spots that displayed similar peptide mass fingerprints shown in Fig 3. pI range, molecular mass (MM) and relative expression were determined by computational analyses of the 2-DE gels. X: unknown amino acid; B: cleavage site; J: juveniles; S: sub-adults, A: adults.

From: Ontogenetic variations in the venom proteome of the Amazonian snake Bothrops atrox

Group

Protein Class

Best Match sptrembl # Organism

Peptide sequences

pI range

MM (kDa)

Relative expression

A

Metalloproteinase

Bothropasin

O93523

Bothrops jararaca

BITVKPDVDYTLNSFAEWR

BASMSECDPAEHCTGQSSECPADVFHK

BMYELANIVNEIFR

BKIPCAPEDVK

BKTDLLTR

BGMVLPGTK

BXXFQDVYEAEDSCFK

QYNPFR

YLEFLLVVDQLLNK

BYNPFR

5.0

52

J = S = A

B

L-amino

oxidase

L-amino oxidase I

Q6TGQ9

Bothrops jararacussu

BXXGQLYEESLQK

BLFLTMNK

BXXTVTYQAVMK

BIKFEPPLPPKK

BRFDEIVGGMDK

BHDDIFAYEK

BXXWYANLGPMRLPEK

BFWEDDGIHGGK

BETDYEEFLEIAK

5.9 –6.2

55 – 61

J = S = A

C

Metalloproteinase

Bothropasin

O93523

Bothrops jararaca

BXXVEVGEECDCGSPR

BXXGTECQAA

DMADLCTGR

BLYCVDSAVNGR

BLYCVDSSPANK

BGMVLPGTK

BKIPCAPEDVK

BYNPFR

BXXFQDVYEAEDSCFK

7.1–7.5

40 – 51

J>S>A

D

Metalloproteinase

Metalloproteinase

Q8QG89

Bothrops insularis

BTLDSFGEWR-BTLDSFEGWR

BTLDSFWWR

BTLDSFWEGR

BTLDSFWGER

BYVDLFLVVDHGVLDNK

BYVDLFLVVDHGMFMK-

BYVDLFLVVDHGXXXK

BDLINVQQDSR

BENPQCILNKR

5.3 – 6.4

23–24

J<S<A

E

Serine proteinase

Bilineobin

Q9PSN3

Agkistrodon bilineatus

BVVGGDECNINEHR

BSLPSSPPSVWSASK

BSLPSSPPSVXXSASK

BDIMLIR

BVMGWGSLSSPK

BFLCNPR

BFLCGGPR

BIFLTCTK

6.3 –6.4

28 – 29

J = S = A

F

CRISP

Ablomin

Q8JI40

Agkistrodon halys blomhoffi

BSVNPTASNMLK

BMEWYPEAAANAER

BKPEIQNEIVDLHNSLR

BSGPPCGDCPSACDDGLCTNPCTK

AGCAAAYCPSSSYK

BXXDFDSESPR

7.1 –8.1

28 – 29

J>S = A

G

Phospholipase A2

Phospholipase A2

Q7ZTA7

Crotalus viridis

BVAVLCFR

FVHDCCYGK

BMDLYTLHR-BMDLYTYDK

8.1

16

J = S = A

H

C-type lectin

Botrocetin β chain

P22030

Bothrops jararaca

Platelet glycoprotein

IB-binding protein

Q9PSM5

Bothrops jararaca

Phospholipase A2

Q8QG87

Bothrops insularis

BDCPSGWSSYEGSCYK

FVVTEYECVASK

BXXSFEWSDGTDLSYK

BXXTQLAYVVCK

-BLAYVVCEAQR

-BLAYVVCK

BTCLGLEEDSGFR

BSLTSPMLK

DNQWLSFPCTR

BXXNAWLGLWEGK

BXXSFEWSDGTDLTYK

BXXWADAESLCALQR

BTCLGLEEDSGFRK

BFCTLQQR

BLLQLLQR

BEEADFVR

BNFVCEFQA

BWWIIPCTR

BVAAICFR

BVAATCFR

BYWLYGAK

4.8

17

J = S<A

I

C-type lectin

Botrocetin α chain

P22029

Bothrops jararaca

BDCPSGWSSYEGNCYK

BLYSGEADFVGDLVTK

BWSDGSSVSYENVVER

BMNWADAER

BKCFALEK

BGGHLVSIK

BCFALEK

BNPFVCK

BFFQQK

5.3

15

J = S<A

J

Phospholipase A2

Myotoxin I

P20474

Bothrops asper

BAAAVCFR

BSLIEFAK

BMILEETK

BKSGVIICGEGTPCEK

BXXAYPDLFCK

BLYSGEADFVVK

BVAVLCFR

BAAGLCGFR

BVTGVPTYK

BSGVIICGE

7.8

17

J = S<A

K

Phospholipase A2

Myotoxin III

Q9PVE3

Bothrops asper

BXXVCDENNPCLK

BXXVCDENNPPGR-VCDENNPCLK

BYFAYPDLFCK

VTSYQY

BMILQETGKNPVTSYGAYGCNCGVLGR

BELCECDKAVAICLR

BAVAICLR

BYSYSWK

7.8

17

J = S<A

L

Metalloproteinase

Berythractivase

Q8UVG0

Bothrops erythromelas

BLTPGSQCADGLCCDQCR

BKYVEFVVVLDHGMYK

BVPLTGLELWSDR

BLYCFLYSSK

VVFEPFK-VVQHQVR

BVPLTXVLDHRFK

KIPCAPEDVK

5.0 –5.9

61 – 66

J>S>A

M

Metalloproteinase

BOJUMET II

Q7T1T5

Bothrops jararacusu

BETVLLNR

BYLIDNRPPCILNIPLR

BFALVGLEMWSNR

BFALVGLDMGWSNR

BSSDLGMVDLASK

VQGPLGNTLTCM

PTDTDFDGTLLGLAWR

TDTDFDGTLLGLAWR

GQSADCPTDDLQR

5.4 –5.7

51–53

J>S>A

N

Serine proteinase

Serine proteinase

Q7T229

Bothrops jararacusu

BLVGGDECNINEHR

BIMGWGTLSPTK

BFLCNPR

BVSDYTEWLK

5.0 –5.3

29 – 30

J>S = A

O

Metalloproteinase

Metalloproteinase

Q8AWX7

Agkistrodon halys palas

BYIELVIVADHR

BSVGIVRDYR

BSVANDDEVIRYPK

5.2 –5.4

36 – 37

J>S>A

P

Metalloproteinase

Factor X activator

heavy chain

Q7T046

Vipera lebetina

BLYETVNALNVLCR

BYSVGLVQDYR

BYIELVIVADHR

BLNLNPDEQR

5.8 –6.2

38 – 40

J>S>A

Q

Serine proteinase

Serine proteinase

Q8QG86

Bothrops insularis

BFLAFLYPGR

BIYLGIHAR

BDIMLIR

BLHEPALYTK

BLQGLVSDHR

BSVANDDP-BSVANDDEE

6.3 –7.4

32 – 34

J = S>A

R

Serine proteinase

Catroxase II

Q8QHK2

Crotalus atrox

BLDDVLDQDLG

BTLCAGILEGGK

BAAYPELPATSR

BAAYPERFTSR

BLPSNPPW-BLPSNPPWHR

BLPSNPPXXXR

6.5

29

J = S>A

S

C-type lectin

Alboaggregin A

subunit 2

P81112

Trimeresurus albolabris

WADAER

SYENWTEAELK

BTCLGLEEDSGFR

BTCLALEEDSGFR

FCAGYLENK

BTPLNLNCR

BXXLNLNCR

BXXTADAER

4.8

17

J>S = A

T

C-type lectin

Mucrocetin

Q6TPG9

Trimeresurus mucrosquamatus

BDCPSGWSSYEGSCYK

BFCTQQQTNHLVSFQSR

BXXCQFVVTEYPSFQSK

BXXSFEWSDGTDLSYK

BXXTQLAYVVCK

BTTENQWWSR

BXXLNLNCR

BLFLQQNK

BLTSPLLR

BMNWEDAEK

4.8

15

J = S>A

U

C-type lectin

Alboagregrina A

P81114

Trimeresurus albolabris

BDCPSDWSSYEGHCYR

BVFNEPQNWADAEK

BQSSEEADFVLK

BSSEEADFVLK

BXXLDQLLK

BLFLQQNK

5.1–5.4

14

J = S>A

V

C-type lectin

Bothrocetin α chain

P22029

Bothrops jararaca

BCFVLER

BXXSDGSCVCYENLVER

BEGFLTWR

BSPMSPDTEEGK

BXXCYENLVER

5.1–5.4

14

J = S>A

X

VEGF

Vascular Endothelial

growth factor

Q90X24

Bothrops insularis

CCTDESLECTATGK

BLEVMKFTEHTNCECR

BETLVSLLEEHPDE

PSCVTALR

BLFRAVLFNALR

5.6 –6.3

13

J>S>A

W

C-type lectin

Botrocetin α chain

P22029

Bothrops jararaca

BDCPSGWSSYEGHCYR

BXXWSDGSSVSYENLVER

VSFQSDWTDFVVK

BLVSFQSDWTDFVVK

BLWADAER

BNPFVCK

BFCSEQAK

BNIQSSDLYAWIGLR

5.9 –6.4

15

J = S>A

Y

Phospholipase A2

Phospholipase A2

Q8QG87

Bothrops insularis

BYFSYGCYCGLGGLGQPR-GSYGCYCLGGL

BXXFVHDCCYGK

BXXXFVHDCCYGK

BXXKDTYNLQYWLYQK-BXXKDTYNLKYWLYAGK

BLTYNLQYWLYQK-BLTYNLKYWLYAAGK

BYGEGLYQK-BYGEGLYAGK

BVVTTCFR

BVAVLCTR

BQLCECDFVA

BXXCECDFV

BXXLWQFGT

6.7

15

J = S>A

Z

C-type lectin

e NGF

Platelet glycoprotein

IB-binding protein

α chain

Q9PSM6

Bothrops jararaca

Nerve growth factor

Q9DEZ9

Crotalus durissus terrificus

BQYFFETK

BALTMEGNQASWR

BIDTACVCVISR

BXXALGQK

BFIRPR

BNPFVCK

BFFQQK

BDTPFECPSDWSTHR

BXXSDGSCVCYENLVR

7.8

17

J = S>A

Δ

Phospholipase A2

Myotoxin III

Q9PVE3

Bothrops asper

BSYAAYGCNCGVLGR

BMLLLETGKLPAK

NLWQLGK

VAVLCFR

BAVAICLR

BYSYSWK

BYNYLKPFCK

BTIVCGENNSCLK

6.4 –8.1

16

J = S>A