Figure 2
From: A systems approach to clinical oncology: Focus on breast cancer
How TMAs are constructed. Cores (0.6–2.0 mm in diameter) are taken from FFPE tumour tissue donor blocks and arrayed into a recipient block. The recipient block is then sectioned (5 μm) onto a glass slide and processed by immunohistochemistry for biomarkers. The analysis can be manual or automated and the data is linked to clinical information.