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Table 1 iTRAQ analysis of differentially expressed proteins between human epithelial ovarian cancer cell lines TOV-112D and TOV-81D†.

From: Comparative proteome analysis of human epithelial ovarian cancer

Accession Entrez Gene GO Gene SwissProt Description Number of unique peptides Protein ratio (112D/81D) %RSD Validation
IPI00008557 10642 RNA metabolism/protein biosynthesis IGF2BP1 Q9NZI8 Insulin-like growth factor 2 mRNA-binding protein 1 2 11,9 81  
IPI00005996 8091 Transcription HMGA2 P52926 High mobility group protein HMGI-C 2 8,1 100  
IPI00218914 216 Response to stress ALDH1A1 P00352 Aldehyde dehydrogenase 1A1 6 5,8 43 2D
IPI00021033 1281 Cell adhesion COL3A1 P02461 Collagen alpha-1(III) chain precursor 4 5,0 79 2D
IPI00014424 1917 Protein biosynthesis EEF1A2 Q05639 Elongation factor 1-alpha 2 3 4,2 80 2D
IPI00028376 1678 Transport/protein metabolism TIMM8A O60220 Mitochondrial import inner membrane translocase subunit Tim8A 2 4,2 14  
IPI00030131 7112 Cytoskeleton organizationanisation TMPO P42167 Lamina-associated polypeptide 2, isoforms beta/gamma 3 3,8 21  
IPI00329745 10128 RNA metabolism LRPPRC P42704 130 kDa leucine-rich protein 3 3,8 30  
IPI00301189 51477 Lipid biosynthesis ISYNA1 Q9NPH2 Myo-inositol 1-phosphate synthase A1 2 3,7 23  
IPI00165467 10643 RNA metabolism/protein biosynthesis IGF2BP3 O00425 Insulin-like growth factor 2 mRNA-binding protein 3 3 3,3 50  
IPI00292387 9221 RNA metabolism NOLC1 Q14978 Nucleolar phosphoprotein p130 2 3,3 22  
IPI00218493 3251 Puridine salvage HPRT1 P00492 Hypoxanthine-guanine phosphoribosyltransferase 2 3,1 15  
IPI00218918 301 Membranes binding/cell motility ANXA1 P04083 Annexin A1 7 3,0 41 2D&WB
IPI00216044 22913 RNA metabolism RALY Q9UKM9 RNA-binding protein Raly 2 3,0 18  
IPI00000105 9961 Response to stress MVP Q14764 Major vault protein 3 0,40 87  
IPI00455315 302 Membranes binding/cell motility ANXA2 P07355 Annexin A2 3 0,40 33  
IPI00477536 2317 Cell motility/Cytoskeleton organization/signal transduction FLNB Q60FE7 Filamin B 2 0,38 47  
IPI00333541 2316 Cell motility/Cytoskeleton organization/signal transduction FLNA P21333 Filamin-A 10 0,36 46  
IPI00296099 7057 Cell motility/cell adhesion THBS1 P07996 Thrombospondin-1 precursor 2 0,35 67  
IPI00013808 81 Cell motility/cell adhesion ACTN4 O43707 Alpha-actinin-4 2 0,33 22  
IPI00029111 1809 Pyrimidine metabolism DPYSL3 Q6DEN2 Dihydropyrimidinase-like 3 protein (DPYSL3 protein) 4 0,30 85 2D
IPI00554788 3875 Cytoskeleton organizationanisation KRT18 P05783 Keratin-18 2 0,29 19  
IPI00306604 3678 Cell adhesion ITGA5 P08648 Integrin alpha-5 precursor 2 0,29 45  
IPI00163187 6624 Cytoskeleton organization/cell motility FSCN1 Q16658 Fascin 2 0,24 18 2D
IPI00031008 3371 Cell adhesion TNC P24821 Tenascin-C 2 0,23 71  
IPI00182373 8974 Collagen biosynthesis P4HA2 O15460 Prolyl 4-hydroxylase subunit alpha-2 precursor 5 0,22 22 2D
IPI00472165 5352 Collagen biosynthesis PLOD2 O00469 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor; 3 0,21 55 2D
IPI00550363 8407 Cytoskeleton organization/cell motility TAGLN2 P37802 Transgelin-2 2 0,20 11 2D&WB
IPI00216138 6876 Cytoskeleton organization/cell motility TAGLN Q01995 Transgelin 5 0,20 58  
IPI00008494 3383 Cell adhesion ICAM1 P05362 Intercellular adhesion molecule 1 precursor (ICAM1) 4 0,17 35  
IPI00216135 7168 Cell motility/cell adhesion TPM1 P09493 Tropomyosin alpha-1 chain 2 0,16 38 2D
IPI00007118 5054 Cell adhesion/motility/urokinase regulation SERPINE1 P05121 Plasminogen activator inhibitor 1 precursor (PAI-1) 2 0,15 27 2D
IPI00414283 2335 Cell motility/cell adhesion FN1 P02751 Fibronectin precursor 2 0,11 8  
IPI00026663 220 Response to stress ALDH1A3 P47895 Aldehyde dehydrogenase 1A3 3 0,11 39 2D
IPI00442073 1465 Cell motility CSRP1 P21291 Cysteine and glycine-rich protein 1 3 0,08 255  
IPI00297646 1277 Cell adhesion COL1A1 P02452 Collagen alpha-1(I) chain precursor 5 0,08 50  
IPI00178352 2318 Cell motility/Cytoskeleton organization/signal transduction FLNC Q14315 Filamin-C 3 0,07 39  
  1. †Selected protein expression ratios were confirmed by western blot (WB) analysis. Differentially expressed proteins also identified by comparative two-dimensional electrophoresis are indicated (2D). %RSD = (standard deviation/mean) × 100