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Table 1 Subset of age-associated proteins from quantitative proteomic analysis of liver peroxisomal proteins. Proteins were identified by MALDI-TOF MS a).

From: Age-related subproteomic analysis of mouse liver and kidney peroxisomes

10 wks 18 mns 24 mns         
A (Fold) SDV(Fold) B (Fold) SDV(Fold) C (Fold) SDV(Fold) Pathway Location NCBI nr Cvage Score p Mr ob pI ob
1 0.29 -2.12 0.03 1.63 0.22 β-oxidation pero gi|66793429 24% 60 0.1 25000 9
1 0.31 -1.62 0.47 3.11 0.52 β-oxidation pero giI30525893 26% 66 0.0251189 40000 9.0
1 0.48 0.00 0.00 2.20 0.52 α-oxidation pero gi|31560355 30% 104 3.981E-06 65000 6.8
1 0.15 -1.48 0.34 -3.28 0.06 isoprenoid biosynthesis pero gi|20965433 33% 68 0.0158489 26000 8.7
1 0.50 -1.31 0.39 2.05 0.69 isoprenoid biosynthesis related pero gi|409499 24% 70 0.01 33000 9.1
1 0.42 2.78 0.43 1.48 0.23 amino acid metabolism pero gi|19388006 24% 63 0.0501187 42000 7.8
1 0.09 1.02 0.25 -3.77 0.13 putative peroxisomal prot pero gi|6678726 18% 60 0.1 67000 6.1
1 0.43 2.14 0.39 -1.09 0.41 putative peroxisomal prot pero gi|6753036 40% 117 1.995E-07 60000 6.6
1 0.18 -1.33 0.10 -2.87 0.13 β-oxidation mito gi|21431780 24% 55 0.3162278 33000 8.8
1 0.21 0.00 0.00 9.36 0.15 β-oxidation mito gi|20810027 23% 70 0.01 46000 7.8
1 0.14 2.26 0.62 1.09 0.29 glutamate biosynthesis mito gi|6680027 22% 64 0.0398107 60000 7.4–7.5
1 0.38 -1.20 0.15 -3.31 0.21 stress response mito gi|14917005 25% 63 0.0501187 75000 6.2
1 0.32 2.52 0.53 1.32 0.38 glutamine metabolism cyt gi|15419027 28% 59 0.1258925 42000 7.5
1 0.05 7.35 0.46 0.00 0.00 protein folding cyt gi|129729 28% 64 0.0398107 61000 5
  1. a) Protein numbers correspond to number from the 2-DE gels shown in Figure 2. Data from molecular mass in kDa and pI can assist the localization in the Figure 2. The 10 weeks old group correspond to A, 18 months old group as B and 24 months old group as C. The 10 weeks old group has been taken as a reference. Therefore, the change in protein expression associated with age is presented as the ratio A/A or B/A or C/A for liver. The ratios were calculated dividing the volume percentage per each spot in the 10 weeks, 18 months or 24 months divide by the volume percentage per spot in the 10 weeks. The standard deviations data are included. The biochemical pathways and subcellular localization are also indicated.