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Table 2 Subset of age-associated proteins from quantitative proteomic analysis of kidney peroxisomal proteins. Proteins were identified by MALDI-TOF MS a).

From: Age-related subproteomic analysis of mouse liver and kidney peroxisomes

10 wks 18 mns 24 mns         
D (Fold) SDV(Fold) E (Fold) SDV(Fold) F (Fold) SDV(Fold) Pathway Location NCBI nr Cvage Score p Mr ob pI ob
1 0.22 -3.4 0.04 1.02 0.06 auxiliary β-oxidation pero gi|6753272 30% 114 3.981E-07 60000 7.5–7.8
1 0.18 -2.27 0.02 1.04 0.12 auxiliary β-oxidation pero gi|6753272 30% 114 3.981E-07 60000 7.5–7.8
1 0.31 -4.16 0.07 -1.86 0.10 β-oxidation pero gi|66793429 24% 60 0.1 25000 9
1 0.16 -1.18 0.46 -3.53 0.13 β-oxidation pero giI30525893 26% 66 0.0251189 40000 9.0
1 0.26 0 0.00 -4.38 0.35 α-oxidation pero gi|6754564 20% 64 0.0398107 36000 7.3
1 0.12 0 0.00 -1.44 0.22 α-oxidation pero gi|31560355 30% 104 3.981E-06 65000 6.8
1 0.29 3.04 0.58 -1.73 0.05 isoprenoid biosynthesis pero gi|20965433 33% 68 0.0158489 26000 8.7
1 0.18 -1.11 0.22 -2.61 0.15 isoprenoid biosynthesis related pero gi|409499 24% 70 0.01 33000 9.1
1 0.14 0 0.00 6.80 1.10 amino acid metabolism pero gi|19388006 24% 63 0.0501187 42000 7.8
1 0.17 4.6 0.36 0.00 0.00 amino acid metobolism pero giI17390882 25% 65 0.0316228 33000 6.0
1 0.10 -1.95 0.16 0.00 0.00 amino acid metobolism pero gi|477004 32% 104 3.981E-06 65000 6.5
1 0.27 -2.88 0.14 1.14 0.19 amino acid metobolism pero gi|477004 32% 104 3.981E-06 65000 6.7
1 0.23 1.24 0.05 -1.59 0.15 purine/pyrimidine metabolism pero gi|18044669 26% 63 0.0501187 35000 9.0–9.1
1 0.27 3.45 0.52 -1.21 0.13 putative peroxisomal protein pero/cyt gi|226778 24% 67 0.0199526 33000 7.5
1 0.19 2.46 0.45 0.00 0.00 putative peroxisomal protein pero gi|76779273 21% 59 0.1258925 62000 5.7–5.9
1 0.14 1.94 0.22 -1.17 0.37 β-oxidation cyt gi|13182962 39% 60 0.1 30000 9.0
1 0.14 10.66 0.10 0.00 0.00 β-oxidation mito gi|21431780 24% 55 0.3162278 33000 8.8
1 0.18 4.3 0.17 0.00 0.00 β-oxidation mito gi|26345684 25% 67 0.0199526 45000 6.5
1 0.19 4.26 0.62 3.58 0.63 glycolysis mito gi|18043470 24% 54 0.3981072 37000 6.1
1 0.24 3.61 0.71 0.00 0.00 stress response mito gi|14917005 25% 63 0.0501187 75000 6.0
1 0.20 3.06 0.22 1.37 0.43 stress response mito gi|14917005 25% 63 0.0501187 75000 6.2
  1. a) Protein numbers correspond to number from the 2-DE gels shown in Figure 2. Data from molecular mass in kDa and pI can assist the localization in the Figure 2. The 10 weeks old group correspond to D, 18 months old group as E and 24 months old group as F. The 10 weeks old group has been taken as a reference. Therefore, the change in protein expression associated with age is presented as the ratio D/D, E/D and F/D for kidney. The ratios were calculated dividing the volume percentage per each spot in the 10 weeks, 18 months or 24 months divide by the volume percentage per spot in the 10 weeks. The standard deviations data are included. The biochemical pathways and subcellular localization are also indicated.