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Table 1 Comparison of adjusted spot volumes of the 7 protein spots that were found to be differently regulated.

From: Identification of differentially regulated proteins in a patient with Leber's Congenital Amaurosis – a proteomic study

Protein No.

Adjusted spot volume (OD × Area)

p-value*

Relative protein levels in LCA to normal

 

LCA (n = 1)

Normal (n = 7) Mean ± SD

  

15

1.066

0.616 ± 0.175

0.042

1.73

23

1.505

0.154 ± 0.016

<0.0001

9.78

28

1.600

0.290 ± 0.116

<0.0001

5.52

36

7.345

3.073 ± 0.719

0.001

2.39

48

0.699

1.192 ± 0.173

0.029

0.59

52

2.000

0.291 ± 0.089

<0.0001

6.88

55

1.498

0.423 ± 0.239

0.004

3.54

  1. *The p-value was calculated by comparing the single observation from LCA with the range observed in the normal retina using the t-distribution (see Materials and Methods).