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Table 2 Cytosolic differentially expressed proteins identification and regulation

From: Proteome alteration induced by hTERT transfection of human fibroblast cells

    

hTERTt-WI38/WI38

hTERT-WI38/HPV-WI38

Reference

Swiss-Prot AC

Gene name, STRING protein association network legend

Protein name

Function

T-test

Regulation

T-test

Regulation

 

[O43852]

CALR

Calumenin precursor

Ca(2+)-binding, secretory pathway

1.0E-03

2.27

1.6E-02

1.5

[40]

[Q15293]

RCN1

Reticulocalbin-1 precursor

Ca(2+)-binding, secretory pathway

1.3E-04

2.11

4.2E-04

1.85

[40]

[P14625]

HSP90B1

Endoplasmin precursor (GRP94)

ER chaperone, Ca(2+) binding, anti-apoptosis

1.4E-05

2.1

1.6E-03

1.26

[47, 59]

[Q14697]

GANAB

Neutral alpha-glucosidase AB precursor

Protein O-glucosyl hydrolase

4.9E-08

2.06

5.5E-06

1.42

 

[O95302]

FKBP9L

FK506-binding protein 9 precursor (FKBP9)

Peptidyp propyl isomerase (PPI), accelerate protein folding

9.9E-05

2.04

3.9E-03

1.41

[52]

[Q9Y4L1]

HYOU1

150 kDa oxygen-regulated protein precursor (ORP150)

ER chaperone, exchange factor for GRP78

1.2E-03

1.98

2.3E-03

1.8

[47, 60]

[Q9BS26]

TXNDC4

Thioredoxin domain-containing protein 4 precursor (ERp44)

Control of oxidating protein folding, ERO1L partner

3.5E-06

1.89

7.2E-05

1.57

[61, 62]

[O43852]

CALU

Calumenin precursor

Ca(2+)-binding, secretory pathway

1.80E-05

1.80

3.7E-03

1.35

[40]

[Q15293]

RCN1

Reticulocalbin-1 precursor

Ca(2+)-binding, secretory pathway

2.5E-02

1.78

6.2E-02

1.51

[40]

[O75131]

CPNE3

Copine-3

Ca(2+)-dependent phospholipid-binding proteins

7.4E-04

1.73

1.2E-03

1.59

[63, 64]

[Q8NBS9]

TXNDC5

Thioredoxin domain-containing protein 5 precursor (Erp46)

Thiol oxydoreductase

3.2E-03

1.73

4.9E-03

1.65

[62, 65]

[P11021]

HSPA5

78 kDa glucose-regulated protein precursor (GRP78)

ER chaperone, Ca(2+)-binding, ER stress sensor, anti-apoptosis

1.5E-02

1.65

7.4E-03

1.57

[47, 66]

[P13674]

P4HA1

Prolyl 4-hydroxylase alpha-1 subunit precursor

Hypoxia-inducible collagen synthesis

2.0E-08

1.65

1.3E-06

1.77

[67]

[O15460]

P4HA2

Prolyl 4-hydroxylase alpha-2 subunit precursor

Hypoxia-inducible collagen synthesis

2.8E-04

1.64

1.5E-03

1.43

[67]

[P07237]

P4HB

Protein disulfide-isomerase precursor

Rearrangement of -S-S-bonds in proteins

2.0E-06

1.64

2.1E-04

1.28

[68]

[Q9H2D6]

TRIOBP

TRIO and F-actin-binding protein

May regulate actin cytoskeletal organization

8.0E-05

1.59

4.9E-03

1.35

 

[P30101]

GRP58

Protein disulfide-isomerase A3 precursor (PDI-A3)

Rearrangement of -S-S-bonds in proteins

8.6E-07

1.57

2.8E-06

1.48

[68]

[Q96HE7]

ERO1L

ERO1-like protein alpha precursor (ERO1L)

Protein disulfide isomerases oxydoreductase

2.7E-02

1.54

4.7E-02

1.44

[61, 69]

[P27797]

CALR

Calreticulin precursor

ER chaperone, Ca(2+)-binding, glycoprotein folding

2.9E-02

1.46

7.8E-03

1.61

[47]

[Q15084]

PDIA6

Protein disulfide-isomerase A6 precursor (PDI-A6)

Rearrangement of -S-S-bonds in proteins

8.8E-05

1.45

1.1E-04

1.31

[68]

[Q99439]

CNN2

Calponin-2

Ca(2+)-binding, actin-binding RNA helicase which

2.1E-04

1.33

2.7E-03

1.25

[70, 71]

[P60842]

EIF4A1

Eukaryotic initiation factor 4A-I

mediates binding of mRNA to the ribosome

6.6E-05

1.33

8.6E-05

1.48

 

[P30101]

GRP58

Protein disulfide-isomerase A3 precursor (PDI-A3)

Rearrangement of -S-S-bonds in proteins

3.9E-03

1.29

2.0E-03

1.44

[68]

[P27797]

CALR

Calreticulin precursor

ER chaperone, Ca(2+)-binding, glycoprotein folding

0.18

1.26

2.6E-02

1.68

[47]

[P51665]

PSMD7

26S proteasome non-ATPase regulatory subunit 7

Regulation of ubiquitinated proteins degradation

2.2E-02

0.76

1.4E-02

0.71

 

[P04406]

HSD35

Glyceraldehyde-3-phosphate dehydrogenase

Glycolytic pathway

1.1E-02

0.75

7.7E-04

0.70

 

[Q99426]

CKAP1

Tubulin-specific chaperone B

Chaperone, tubulin organisation

1.3E-03

0.75

8.8E-04

0.72

 

[P04406]

HSD35

Glyceraldehyde-3-phosphate dehydrogenase

Glycolytic pathway

4.9E-03

0.74

9.4E-03

0.76

 

[P09211]

GSTP1

Glutathione S-transferase P

Oxidative stress

6.1E-03

0.72

4.7E-02

0.81

 

[P04075]

ALDOA

Fructose-bisphosphate aldolase A

Glycolytic pathway

6.4E-03

0.71

7.2E-02

0.85

 

[P04075]

ALDOA

Fructose-bisphosphate aldolase A

Glycolytic pathway

8.2E-04

0.69

4.7E-02

0.75

 

[P04406]

HSD35

Glyceraldehyde-3-phosphate dehydrogenase

Glycolytic pathway

1.2E-03

0.61

1.3E-03

0.69

 

[P04792]

HSPB1

Heat-shock protein beta-1 (HSP27)

Chaperone, actin organization

3.8E-03

0.61

3.4E-03

0.65

 

[P05120]

SERPINB2

Plasminogen activator inhibitor 2 precursor

Plasminogen activator inhibitor

3.3E-04

0.56

1.3E-03

0.59

 

[P17987]

TCP1

T-complex protein 1 subunit alpha

Chaperone, protein folding, actin and tubulin folding

1.7E-02

0.56

3.7E-03

0.67

 

[P08758]

ANXA5

Annexin A5

Ca(2+)-dependant phospholipids-binding, apoptosis regulation

2.1E-04

0.39

2.6E-04

0.40

 

[P07737]

PFN1

Profilin-1

Intranuclear movements, assembly of transcription complexes

3.3E-04

0.38

1.0E-02

0.33

 

[P07737]

PFN1

Profilin-1

Intranuclear movements, assembly of transcription complexes

3.2E-02

0.37

2.7E-02

0.4

 
  1. List of the proteins differentially expressed due to hTERT transfection in the cytosolic fraction of human WI38 cells. Listed by decreasing regulation.