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Table 2 Cytosolic differentially expressed proteins identification and regulation

From: Proteome alteration induced by hTERT transfection of human fibroblast cells

     hTERTt-WI38/WI38 hTERT-WI38/HPV-WI38 Reference
Swiss-Prot AC Gene name, STRING protein association network legend Protein name Function T-test Regulation T-test Regulation  
[O43852] CALR Calumenin precursor Ca(2+)-binding, secretory pathway 1.0E-03 2.27 1.6E-02 1.5 [40]
[Q15293] RCN1 Reticulocalbin-1 precursor Ca(2+)-binding, secretory pathway 1.3E-04 2.11 4.2E-04 1.85 [40]
[P14625] HSP90B1 Endoplasmin precursor (GRP94) ER chaperone, Ca(2+) binding, anti-apoptosis 1.4E-05 2.1 1.6E-03 1.26 [47, 59]
[Q14697] GANAB Neutral alpha-glucosidase AB precursor Protein O-glucosyl hydrolase 4.9E-08 2.06 5.5E-06 1.42  
[O95302] FKBP9L FK506-binding protein 9 precursor (FKBP9) Peptidyp propyl isomerase (PPI), accelerate protein folding 9.9E-05 2.04 3.9E-03 1.41 [52]
[Q9Y4L1] HYOU1 150 kDa oxygen-regulated protein precursor (ORP150) ER chaperone, exchange factor for GRP78 1.2E-03 1.98 2.3E-03 1.8 [47, 60]
[Q9BS26] TXNDC4 Thioredoxin domain-containing protein 4 precursor (ERp44) Control of oxidating protein folding, ERO1L partner 3.5E-06 1.89 7.2E-05 1.57 [61, 62]
[O43852] CALU Calumenin precursor Ca(2+)-binding, secretory pathway 1.80E-05 1.80 3.7E-03 1.35 [40]
[Q15293] RCN1 Reticulocalbin-1 precursor Ca(2+)-binding, secretory pathway 2.5E-02 1.78 6.2E-02 1.51 [40]
[O75131] CPNE3 Copine-3 Ca(2+)-dependent phospholipid-binding proteins 7.4E-04 1.73 1.2E-03 1.59 [63, 64]
[Q8NBS9] TXNDC5 Thioredoxin domain-containing protein 5 precursor (Erp46) Thiol oxydoreductase 3.2E-03 1.73 4.9E-03 1.65 [62, 65]
[P11021] HSPA5 78 kDa glucose-regulated protein precursor (GRP78) ER chaperone, Ca(2+)-binding, ER stress sensor, anti-apoptosis 1.5E-02 1.65 7.4E-03 1.57 [47, 66]
[P13674] P4HA1 Prolyl 4-hydroxylase alpha-1 subunit precursor Hypoxia-inducible collagen synthesis 2.0E-08 1.65 1.3E-06 1.77 [67]
[O15460] P4HA2 Prolyl 4-hydroxylase alpha-2 subunit precursor Hypoxia-inducible collagen synthesis 2.8E-04 1.64 1.5E-03 1.43 [67]
[P07237] P4HB Protein disulfide-isomerase precursor Rearrangement of -S-S-bonds in proteins 2.0E-06 1.64 2.1E-04 1.28 [68]
[Q9H2D6] TRIOBP TRIO and F-actin-binding protein May regulate actin cytoskeletal organization 8.0E-05 1.59 4.9E-03 1.35  
[P30101] GRP58 Protein disulfide-isomerase A3 precursor (PDI-A3) Rearrangement of -S-S-bonds in proteins 8.6E-07 1.57 2.8E-06 1.48 [68]
[Q96HE7] ERO1L ERO1-like protein alpha precursor (ERO1L) Protein disulfide isomerases oxydoreductase 2.7E-02 1.54 4.7E-02 1.44 [61, 69]
[P27797] CALR Calreticulin precursor ER chaperone, Ca(2+)-binding, glycoprotein folding 2.9E-02 1.46 7.8E-03 1.61 [47]
[Q15084] PDIA6 Protein disulfide-isomerase A6 precursor (PDI-A6) Rearrangement of -S-S-bonds in proteins 8.8E-05 1.45 1.1E-04 1.31 [68]
[Q99439] CNN2 Calponin-2 Ca(2+)-binding, actin-binding RNA helicase which 2.1E-04 1.33 2.7E-03 1.25 [70, 71]
[P60842] EIF4A1 Eukaryotic initiation factor 4A-I mediates binding of mRNA to the ribosome 6.6E-05 1.33 8.6E-05 1.48  
[P30101] GRP58 Protein disulfide-isomerase A3 precursor (PDI-A3) Rearrangement of -S-S-bonds in proteins 3.9E-03 1.29 2.0E-03 1.44 [68]
[P27797] CALR Calreticulin precursor ER chaperone, Ca(2+)-binding, glycoprotein folding 0.18 1.26 2.6E-02 1.68 [47]
[P51665] PSMD7 26S proteasome non-ATPase regulatory subunit 7 Regulation of ubiquitinated proteins degradation 2.2E-02 0.76 1.4E-02 0.71  
[P04406] HSD35 Glyceraldehyde-3-phosphate dehydrogenase Glycolytic pathway 1.1E-02 0.75 7.7E-04 0.70  
[Q99426] CKAP1 Tubulin-specific chaperone B Chaperone, tubulin organisation 1.3E-03 0.75 8.8E-04 0.72  
[P04406] HSD35 Glyceraldehyde-3-phosphate dehydrogenase Glycolytic pathway 4.9E-03 0.74 9.4E-03 0.76  
[P09211] GSTP1 Glutathione S-transferase P Oxidative stress 6.1E-03 0.72 4.7E-02 0.81  
[P04075] ALDOA Fructose-bisphosphate aldolase A Glycolytic pathway 6.4E-03 0.71 7.2E-02 0.85  
[P04075] ALDOA Fructose-bisphosphate aldolase A Glycolytic pathway 8.2E-04 0.69 4.7E-02 0.75  
[P04406] HSD35 Glyceraldehyde-3-phosphate dehydrogenase Glycolytic pathway 1.2E-03 0.61 1.3E-03 0.69  
[P04792] HSPB1 Heat-shock protein beta-1 (HSP27) Chaperone, actin organization 3.8E-03 0.61 3.4E-03 0.65  
[P05120] SERPINB2 Plasminogen activator inhibitor 2 precursor Plasminogen activator inhibitor 3.3E-04 0.56 1.3E-03 0.59  
[P17987] TCP1 T-complex protein 1 subunit alpha Chaperone, protein folding, actin and tubulin folding 1.7E-02 0.56 3.7E-03 0.67  
[P08758] ANXA5 Annexin A5 Ca(2+)-dependant phospholipids-binding, apoptosis regulation 2.1E-04 0.39 2.6E-04 0.40  
[P07737] PFN1 Profilin-1 Intranuclear movements, assembly of transcription complexes 3.3E-04 0.38 1.0E-02 0.33  
[P07737] PFN1 Profilin-1 Intranuclear movements, assembly of transcription complexes 3.2E-02 0.37 2.7E-02 0.4  
  1. List of the proteins differentially expressed due to hTERT transfection in the cytosolic fraction of human WI38 cells. Listed by decreasing regulation.