From: Proteome alteration induced by hTERT transfection of human fibroblast cells
 |  |  |  | hTERTt-WI38/WI38 | hTERT-WI38/HPV-WI38 | Reference | ||
---|---|---|---|---|---|---|---|---|
Swiss-Prot AC | Gene name, STRING protein association network legend | Protein name | Function | T-test | Regulation | T-test | Regulation | Â |
[O43852] | CALR | Calumenin precursor | Ca(2+)-binding, secretory pathway | 1.0E-03 | 2.27 | 1.6E-02 | 1.5 | [40] |
[Q15293] | RCN1 | Reticulocalbin-1 precursor | Ca(2+)-binding, secretory pathway | 1.3E-04 | 2.11 | 4.2E-04 | 1.85 | [40] |
[P14625] | HSP90B1 | Endoplasmin precursor (GRP94) | ER chaperone, Ca(2+) binding, anti-apoptosis | 1.4E-05 | 2.1 | 1.6E-03 | 1.26 | [47, 59] |
[Q14697] | GANAB | Neutral alpha-glucosidase AB precursor | Protein O-glucosyl hydrolase | 4.9E-08 | 2.06 | 5.5E-06 | 1.42 | Â |
[O95302] | FKBP9L | FK506-binding protein 9 precursor (FKBP9) | Peptidyp propyl isomerase (PPI), accelerate protein folding | 9.9E-05 | 2.04 | 3.9E-03 | 1.41 | [52] |
[Q9Y4L1] | HYOU1 | 150 kDa oxygen-regulated protein precursor (ORP150) | ER chaperone, exchange factor for GRP78 | 1.2E-03 | 1.98 | 2.3E-03 | 1.8 | [47, 60] |
[Q9BS26] | TXNDC4 | Thioredoxin domain-containing protein 4 precursor (ERp44) | Control of oxidating protein folding, ERO1L partner | 3.5E-06 | 1.89 | 7.2E-05 | 1.57 | [61, 62] |
[O43852] | CALU | Calumenin precursor | Ca(2+)-binding, secretory pathway | 1.80E-05 | 1.80 | 3.7E-03 | 1.35 | [40] |
[Q15293] | RCN1 | Reticulocalbin-1 precursor | Ca(2+)-binding, secretory pathway | 2.5E-02 | 1.78 | 6.2E-02 | 1.51 | [40] |
[O75131] | CPNE3 | Copine-3 | Ca(2+)-dependent phospholipid-binding proteins | 7.4E-04 | 1.73 | 1.2E-03 | 1.59 | [63, 64] |
[Q8NBS9] | TXNDC5 | Thioredoxin domain-containing protein 5 precursor (Erp46) | Thiol oxydoreductase | 3.2E-03 | 1.73 | 4.9E-03 | 1.65 | [62, 65] |
[P11021] | HSPA5 | 78 kDa glucose-regulated protein precursor (GRP78) | ER chaperone, Ca(2+)-binding, ER stress sensor, anti-apoptosis | 1.5E-02 | 1.65 | 7.4E-03 | 1.57 | [47, 66] |
[P13674] | P4HA1 | Prolyl 4-hydroxylase alpha-1 subunit precursor | Hypoxia-inducible collagen synthesis | 2.0E-08 | 1.65 | 1.3E-06 | 1.77 | [67] |
[O15460] | P4HA2 | Prolyl 4-hydroxylase alpha-2 subunit precursor | Hypoxia-inducible collagen synthesis | 2.8E-04 | 1.64 | 1.5E-03 | 1.43 | [67] |
[P07237] | P4HB | Protein disulfide-isomerase precursor | Rearrangement of -S-S-bonds in proteins | 2.0E-06 | 1.64 | 2.1E-04 | 1.28 | [68] |
[Q9H2D6] | TRIOBP | TRIO and F-actin-binding protein | May regulate actin cytoskeletal organization | 8.0E-05 | 1.59 | 4.9E-03 | 1.35 | Â |
[P30101] | GRP58 | Protein disulfide-isomerase A3 precursor (PDI-A3) | Rearrangement of -S-S-bonds in proteins | 8.6E-07 | 1.57 | 2.8E-06 | 1.48 | [68] |
[Q96HE7] | ERO1L | ERO1-like protein alpha precursor (ERO1L) | Protein disulfide isomerases oxydoreductase | 2.7E-02 | 1.54 | 4.7E-02 | 1.44 | [61, 69] |
[P27797] | CALR | Calreticulin precursor | ER chaperone, Ca(2+)-binding, glycoprotein folding | 2.9E-02 | 1.46 | 7.8E-03 | 1.61 | [47] |
[Q15084] | PDIA6 | Protein disulfide-isomerase A6 precursor (PDI-A6) | Rearrangement of -S-S-bonds in proteins | 8.8E-05 | 1.45 | 1.1E-04 | 1.31 | [68] |
[Q99439] | CNN2 | Calponin-2 | Ca(2+)-binding, actin-binding RNA helicase which | 2.1E-04 | 1.33 | 2.7E-03 | 1.25 | [70, 71] |
[P60842] | EIF4A1 | Eukaryotic initiation factor 4A-I | mediates binding of mRNA to the ribosome | 6.6E-05 | 1.33 | 8.6E-05 | 1.48 | Â |
[P30101] | GRP58 | Protein disulfide-isomerase A3 precursor (PDI-A3) | Rearrangement of -S-S-bonds in proteins | 3.9E-03 | 1.29 | 2.0E-03 | 1.44 | [68] |
[P27797] | CALR | Calreticulin precursor | ER chaperone, Ca(2+)-binding, glycoprotein folding | 0.18 | 1.26 | 2.6E-02 | 1.68 | [47] |
[P51665] | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | Regulation of ubiquitinated proteins degradation | 2.2E-02 | 0.76 | 1.4E-02 | 0.71 | Â |
[P04406] | HSD35 | Glyceraldehyde-3-phosphate dehydrogenase | Glycolytic pathway | 1.1E-02 | 0.75 | 7.7E-04 | 0.70 | Â |
[Q99426] | CKAP1 | Tubulin-specific chaperone B | Chaperone, tubulin organisation | 1.3E-03 | 0.75 | 8.8E-04 | 0.72 | Â |
[P04406] | HSD35 | Glyceraldehyde-3-phosphate dehydrogenase | Glycolytic pathway | 4.9E-03 | 0.74 | 9.4E-03 | 0.76 | Â |
[P09211] | GSTP1 | Glutathione S-transferase P | Oxidative stress | 6.1E-03 | 0.72 | 4.7E-02 | 0.81 | Â |
[P04075] | ALDOA | Fructose-bisphosphate aldolase A | Glycolytic pathway | 6.4E-03 | 0.71 | 7.2E-02 | 0.85 | Â |
[P04075] | ALDOA | Fructose-bisphosphate aldolase A | Glycolytic pathway | 8.2E-04 | 0.69 | 4.7E-02 | 0.75 | Â |
[P04406] | HSD35 | Glyceraldehyde-3-phosphate dehydrogenase | Glycolytic pathway | 1.2E-03 | 0.61 | 1.3E-03 | 0.69 | Â |
[P04792] | HSPB1 | Heat-shock protein beta-1 (HSP27) | Chaperone, actin organization | 3.8E-03 | 0.61 | 3.4E-03 | 0.65 | Â |
[P05120] | SERPINB2 | Plasminogen activator inhibitor 2 precursor | Plasminogen activator inhibitor | 3.3E-04 | 0.56 | 1.3E-03 | 0.59 | Â |
[P17987] | TCP1 | T-complex protein 1 subunit alpha | Chaperone, protein folding, actin and tubulin folding | 1.7E-02 | 0.56 | 3.7E-03 | 0.67 | Â |
[P08758] | ANXA5 | Annexin A5 | Ca(2+)-dependant phospholipids-binding, apoptosis regulation | 2.1E-04 | 0.39 | 2.6E-04 | 0.40 | Â |
[P07737] | PFN1 | Profilin-1 | Intranuclear movements, assembly of transcription complexes | 3.3E-04 | 0.38 | 1.0E-02 | 0.33 | Â |
[P07737] | PFN1 | Profilin-1 | Intranuclear movements, assembly of transcription complexes | 3.2E-02 | 0.37 | 2.7E-02 | 0.4 | Â |