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Table 3 Nuclear differentially expressed proteins identification and regulation

From: Proteome alteration induced by hTERT transfection of human fibroblast cells

    

hTERTt-WI38/WI38

hTERT-WI38/HPV-WI38

Swiss-Prot AC

Gene name, STRING protein association network legend

Protein name

Function

T-test

Regulation

T-test

Regulation

[P31943]

HNRPH1

Heterogeneous nuclear ribonucleoprotein H

Pre-mRNAs processing

4.4E-03

1.73

3.0E-02

1.58

[P08235]

NR3C2

Mineralocorticoid receptor

Binds to mineralocorticoid response elements (MRE) and transactivates target genes

6.1E-03

1.65

1.6E-02

1.53

[O14579]

COPE

Coatomer subunit epsilon

Implicated in vesicles trafficking

4.2E-02

1.62

0.12

1.33

[Q05048]

CSTF1

Cleavage stimulation factor 50 kDa subunit

Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

1.5E-03

1.57

5.6E-03

1.64

[P07900]

HSPCA

Heat shock protein HSP 90-alpha

Chaperone, 680kDa human telomerase complex partner [72]

1.5E-02

1.42

2.2E-04

2.05

[P62826]

ARA24

GTP-binding nuclear protein Ran

nucleocytoplasmic transport

2.0E-02

1.37

6.7E-03

1.24

[O43809]

ENSP0000030 0291

Cleavage and polyadenylation specificity factor 5

Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs

1.6E-02

1.35

-

1.35

[Q13838]

ATP6V1G2

splicesome RNA helicase BAT1

Splice factor, required for mRNA export

6.3E-03

1.34

1.7E-03

1.5

[P25788]

PSMA3

Proteasome subunit alpha type 3

Protein degradation

5.6E-03

0.68

4.7E-02

0.75

[P28072]

PSMB6

Proteasome subunit beta type 6 precursor

Protein degradation

3.8E-05

0.65

3.0E-04

0.66

[P08865]

RPSA

40S ribosomal protein SA

Protein synthesis

1.3E-04

0.58

5.4E-04

0.60

[P60842]

EIF4A1

Eukaryotic initiation factor 4A-I

RNA helicase which mediates binding of mRNA to the ribosome

3.1E-02

0.54

1.2E-01

0.52

[P09382]

LGALS1

Galectin-1

Cell growth, apoptosis and cell differentiation

8.8E-07

0.50

1.2E-06

0.51

[Q12906]

ILF3

Interleukin enhancer-binding factor 3

Translation inhibitory protein of acid beta-glucosidase and other mRNAs, IL2 transcription regulator, promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA

1.1E-05

0.47

9.5E-04

0.66

  1. List of the proteins differentially expressed due to hTERT transfection in the nuclear fraction of human WI38 cells. Listed by decreasing regulation.
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Proteome Science

ISSN: 1477-5956