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Table 3 Nuclear differentially expressed proteins identification and regulation

From: Proteome alteration induced by hTERT transfection of human fibroblast cells

     hTERTt-WI38/WI38 hTERT-WI38/HPV-WI38
Swiss-Prot AC Gene name, STRING protein association network legend Protein name Function T-test Regulation T-test Regulation
[P31943] HNRPH1 Heterogeneous nuclear ribonucleoprotein H Pre-mRNAs processing 4.4E-03 1.73 3.0E-02 1.58
[P08235] NR3C2 Mineralocorticoid receptor Binds to mineralocorticoid response elements (MRE) and transactivates target genes 6.1E-03 1.65 1.6E-02 1.53
[O14579] COPE Coatomer subunit epsilon Implicated in vesicles trafficking 4.2E-02 1.62 0.12 1.33
[Q05048] CSTF1 Cleavage stimulation factor 50 kDa subunit Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs 1.5E-03 1.57 5.6E-03 1.64
[P07900] HSPCA Heat shock protein HSP 90-alpha Chaperone, 680kDa human telomerase complex partner [72] 1.5E-02 1.42 2.2E-04 2.05
[P62826] ARA24 GTP-binding nuclear protein Ran nucleocytoplasmic transport 2.0E-02 1.37 6.7E-03 1.24
[O43809] ENSP0000030 0291 Cleavage and polyadenylation specificity factor 5 Polyadenylation and 3'-end cleavage of mammalian pre-mRNAs 1.6E-02 1.35 - 1.35
[Q13838] ATP6V1G2 splicesome RNA helicase BAT1 Splice factor, required for mRNA export 6.3E-03 1.34 1.7E-03 1.5
[P25788] PSMA3 Proteasome subunit alpha type 3 Protein degradation 5.6E-03 0.68 4.7E-02 0.75
[P28072] PSMB6 Proteasome subunit beta type 6 precursor Protein degradation 3.8E-05 0.65 3.0E-04 0.66
[P08865] RPSA 40S ribosomal protein SA Protein synthesis 1.3E-04 0.58 5.4E-04 0.60
[P60842] EIF4A1 Eukaryotic initiation factor 4A-I RNA helicase which mediates binding of mRNA to the ribosome 3.1E-02 0.54 1.2E-01 0.52
[P09382] LGALS1 Galectin-1 Cell growth, apoptosis and cell differentiation 8.8E-07 0.50 1.2E-06 0.51
[Q12906] ILF3 Interleukin enhancer-binding factor 3 Translation inhibitory protein of acid beta-glucosidase and other mRNAs, IL2 transcription regulator, promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA 1.1E-05 0.47 9.5E-04 0.66
  1. List of the proteins differentially expressed due to hTERT transfection in the nuclear fraction of human WI38 cells. Listed by decreasing regulation.