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Table 2 Summary of results from mass spectrometry analyses.

From: Multidimensional protein fractionation using ProteomeLab PF 2D™ for profiling amyotrophic lateral sclerosis immunity: A preliminary report

Protein No Protein Fraction ID: Patient Sample MW NCBI Accession # pI
1 Hemopexin F1: 1A,2A,3B,3A
F8: 1B,1A,2B,2A,3B
F6: 1B,1A,2B,2A,3B,3A
F5: 1B,1A,2B,2A,3B,3A
F7: 1B,1A,2B,3B
51676 11321561 6.55
2 Plasminogen F1: 1A,2A,3B,3A
F4: 1A,2A,3B,3A
F6: 2a
90569 4505881 7.04
3 Anti-thrombin F1: 2A,3B 13788 23978644 5.91
4 Histidine-rich glycoprotein precursor F1: 1B,1A,3B
F4: 1B,1A,2B,2A,3B,3A
F9: 2B
59578 4504489 7.09
5 Complement Factor I F5: 1A,2B,2° 65720 119392081 7.72
6 Complex of the Catalytic Domain of Human Plasmin and Streptokinase F1: 1A,2A,3B
F4: 1A,2B,2A,3B,3A
F9: 2B
27286 5821850 8.27
7 Prealbumin F1: 2A
F5: 1B,2B,2A,3B
15919 219978 5.52
8 A Chain A, prealbumin F1: 2A
F8: 1B
F5: 1B,2B,2A,3B
13760 230651 5.55
9 Beta-2 glycoprotein I apolipoprotein H F1: 1A,3B
F4: 1A,2A
F6: 1A,2B,2A,3B
38312 28810 8.34
10 Gelsolin isoform a precursor F1: 3B
F9: 2B
F6: 2B
F5: 1B,3B,3A
85697 4504165 5.90
11 Kringle 2 Domain of Human Plasminogen F4: 1A,2A,3B 9637 6573460 7.55
12 Complement factor H-related protein 1 precursor (FHR-1) F6: 1A,2B,2A,3B
F7: 2A
37661 543981 7.75
13 H factor (complement)-like 3 F6: 2A 30651 5031695 6.00
14 Retinol-binding protein 4, plasma precursor F1: 2B
F5: 2B
23010 55743122 5.76
15 Coagulation factor XII-Mie F5: 2A 67735 24899162 8.03
16 Glutathione peroxidase 3 precursor F5: 2A 25505 121672 8.20
17 Factor H F7: 2A 139125 31965 6.28
  1. Identification by LCMS/MS of proteins in plasma from three ALS patients before (B) and after (A) GA immunization. Only proteins with two or greater sequenced peptides are listed. Coordinates for Fraction IDs are listed in Table 1.