Figure 1
From: High throughput protein-protein interaction data: clues for the architecture of protein complexes
Two-dimensional structural representations of the proteasome, overlaid with filtered yeast interactome (FYI) and predicted domain-domain interaction (DDI) data. (A) The 2-D representation of the 19S RP is built from genetic, biochemical and mass-spectrometric data (see Methods) and the representation of the 20S CP is built from the known 3-D structure. Note that the proteasome is symmetrical and thus we show only the top half here. (B) Pairwise protein interaction data from FYI clearly groups proteins of the 19S RP and 20S CP into two separate groups but show interactions between non-adjacent proteins. (C) Predicted domain-domain interactions are seen between members of the proteasome base. They are also seen within and between the α and β rings of the 20S CP. (D) The intersection of FYI pairwise interactions and predicted domain-domain interactions.