Figure 2

Panel showing that peak alignment by dewarping facilitates investigation of differential responses. A typical plasma chromatogram is shown (A). Sections (250–700 seconds) of plasma peptide chromatograms from rats exposed to clean air and EHC-93 illustrate peak shifts that occurred before dewarping (B) and improved peak alignment by dewarping (E). Better alignment of peaks in dewarped chromatograms resulted in more reliable average chromatograms (F) than those obtained with non-dewarped chromatograms (C), for differential comparisons. The difference chromatograms further facilitate visualization of treatment effects (D and G).