Figure 3
From: Data mining of plasma peptide chromatograms for biomarkers of air contaminant exposures
Effects of dewarping on recalibration by ClinproTools. Both dewarped and non-dewarped plasma peptide chromatograms were mined by ClinproTools. Shown is a comparison of the two exposure groups (air exposure with 0 or 24 h recovery post-exposure, n = 12; EHC-93 exposure with 0 or 24 h recovery post-exposure, n = 12). Poor alignment of peaks in the non-dewarped datasets rendered many chromatograms non-recalibratable (highlighted in the gel-view), and therefore less reliable for use in biomarker analysis. In addition, the peptide profiles of the total average chromatograms were less impacted by the magnitude of peak shift window when using dewarped datasets (spectral view).