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Table 1 Differential expression of endothelial cell proteins evoked by exposure to recombinant human endorepellin

From: Proteomic profiling of endorepellin angiostatic activity on human endothelial cells

Spot number (see Fig. 2) Protein ID Gene name NCBI Accession Number Mr (kDa) pI Response to endorepellin (mean fold change) p-value Reported functions a
1 Calreticulin CALR 4757900 48 4.14 ↓ Downregulated, 0.642 0.0881 Molecular calcium binding and chaperone protein
2 β-actin ACTB 4501885 42 5.18 ↓ Downregulated, 0.403 0.0023 Cellular structure, motility and integrity
3 Chaperonin/Hsp60 HSPD1 31542947 61 5.59 ↓ Downregulated, 0.714 0.1262 Mitochondrial protein assembly, prevention of misfolding, produced under stress within the mitochondrial matrix
4 Vimentin VIM 4507895 54 4.91 ↑ Upregulated, 3.178 0.0276 Class III intermediate filament, cytoskeletal crosstalk, intracellular communication, influence cell shape, adhesion and migration, signalling events
5 Prolyl 4-hydroxylase, β subunit P4HB 20070125 57 4.61 ↑ Absent from Controlb - Key subunit of prolyl 4-hydroxylase enzyme, identical to protein disulfide isomerase
  1. aAs reported in the protein database on the ExPASy web server and in the NCBI Entrez Protein database.
  2. bTrace amounts of this enzyme were found by immunoblotting (see Figure 3 E)